Impact of depressive symptoms on subjective well-being: the importance of patient-reported outcomes in schizophrenia

Figures & data

Table 1 Patient demographics and clinical characteristics

	N = 97
Age (years) mean (SD)	35.0 (10.0)
Gender (male) (%)	72.0
Living status (alone) (%)	11.5
Marital status (single) (%)	92.8
Age at onset (years), mean (SD)	22.0 (8.0)
Number of hospitalizations (median) (SD)	3.0 (3.7)
CGI-S score (mean) (SD)	3.6 (1.3)
PANSS total score (mean) (SD)	65.0 (21.4)
SWN-K total score (mean) (SD)	83.5 (14.0)

Abbreviations: CGI-S, Clinical Global Impression – Severity Scale; PANSS, Positive and Negative Syndrome Scale; SWN-K, Subjective Well-Being under Neuroleptic scale – short version.

Table 2 Spearman correlations and area under the curve between SWN-K and CDSS

SWN-K	CDSS total score rho (95% CI)*	CDSS 4/5 cut-off AUC (95% CI)
Total score	−0.59 (−0.71 to −0.44)	0.84 (0.75 to 0.92)
Mental functioning	−0.47 (−0.61 to −0.30)	0.73 (0.61 to 0.84)
Social integration	−0.46 (−0.60 to −0.29)	0.78 (0.68 to 0.88)
Emotional regulation	−0.51 (−0.64 to −0.34)	0.80 (0.70 to 0.89)
Physical functioning	−0.48 (−0.62 to −0.31)	0.77 (0.67 to 0.87)
Self-control	−0.41 (−0.56 to −0.22)	0.77 (0.68 to 0.87)

* Note: All P-values <0.0001.

Abbreviations: SWN-K, Subjective Well-being under Neuroleptic Scale – short version; CDSS, Calgary Depression Scale for Schizophrenia; AUC, area under the curve; CI, confidence interval.

Table 3 Discriminative performance of the SWN-K against CDSS depression levels

SWN-K	CDSS ≤ 3 Mean (SD)	4 ≥ CDSS ≤ 6 Mean (SD)	CDSS ≥ 7 Mean (SD)
Total score	89.8 (10.6)	81.1 (10.0)	66.9 (12.7)
Mental functioning	17.0 (3.0)	15.8 (3.4)	11.7 (4.2)
Social integration	17.8 (3.3)	16.3 (3.3)	13.2 (2.9)
Emotional regulation	18.9 (2.9)	15.8 (2.7)	14.0 (4.3)
Physical functioning	18.6 (3.1)	17.0 (3.3)	13.8 (3.3)
Self-control	17.6 (2.9)	16.7 (2.5)	13.6 (2.7)

Note: All P-values for linear trend <0.001.

Abbreviations: SWN-K, Subjective Well-being under Neuroleptic scale – short version; CDSS, Calgary Depression Scale for Schizophrenia; SD, standard deviation.