Patients’ Preference for Long-Acting Injectable versus Oral Antipsychotics in Schizophrenia: Results from the Patient-Reported Medication Preference Questionnaire

Figures & data

Figure 1 Medication preference questionnaire.

Table 1 Demographics and Baseline Characteristics

Characteristics	Preference		Total n=1402
	LAI n=1082	Oral (Pills) n=320
Age (years), mean (SD)	38.2 (11.8)	39.0 (12.1)	38.4 (11.9)
Sex, n (%)
Men	575 (53.1)	187 (58.4)	762 (54.4)
Race, n (%)
White	640 (59.1)	120 (37.5)	760 (54.2)
Black	64 (5.9)	47 (14.7)	111 (7.9)
Others	378 (34.9)	153 (47.8)	531 (37.9)
Age at schizophrenia diagnosis (years), mean (SD)	27.6 (9.1)	27.2 (9.3)	27.5 (9.2)
Number of prior hospitalizations, n (%)
None	340 (31.4)	105 (32.8)	445 (31.7)
One	329 (30.4)	92 (28.8)	421 (30.0)
≥Two	413 (38.2)	123 (38.4)	536 (38.2)
Duration of prior hospitalizations (days), n (%)
0–14	419 (47.6)	124 (51.4)	543 (48.4)
15–30	102 (11.6)	26 (10.8)	128 (11.2)
>30	359 (40.8)	91 (37.8)	450 (40.1)
BMI, n (%)
Normal	472 (43.6)	140 (43.8)	612 (43.7)
Overweight	351 (32.4)	101 (31.6)	452 (32.2)
Obese	259 (23.9)	79 (24.7)	338 (24.1)
Country/Region, n (%)
North America (USA)	97 (8.9)	67 (20.9)	164 (11.7)
Europe	557 (51.5)	76 (23.8)	633 (45.1)
Other	428 (39.6)	177 (55.3)	605 (43.2)

Abbreviations: BMI, body mass index; SD, standard deviation; USA, United States of America.

Figure 2 Treatment goals/outcomes cited as important or not important for medication preference.

Abbreviation: LAI, long-acting injectable.

Figure 3 Reasons for preference for LAI vs oral antipsychotics.

Abbreviation: LAI, long-acting injectable.

Figure 4 Reasons for injection-site preference: deltoid vs gluteal.

Figure 5 Medication preference based on dosing frequency and reasons for preference.

Abbreviation: LAI, long-acting injectable.

Table 2 Effect of Baseline Characteristics on Patients’ Medication Preference (LAI vs Pills)

Variable	Unadjusted		Adjusted
	Odds Ratio (95% CI)	p-value	Odds Ratio (95% CI)	p-value
Race (White)	2.41 (1.87; 3.12)	<0.001	2.39 (1.77; 3.23)	<0.001
Country (USA)	0.87 (0.81; 0.92)	<0.001	0.41 (0.27; 0.62)	<0.001
Sex (Women)	1.24 (0.96; 1.60)	0.095	1.25 (0.92; 1.70)	0.150
Age (18–50 years)	1.05 (0.80; 1.38)	0.696	1.08 (0.73; 1.59)	0.710
BMI (normal)	0.99 (0.77; 1.28)	0.968	0.95 (0.70; 1.30)	0.745
Age of diagnosis (≤25 years)	0.81 (0.63; 1.03)	0.088	0.88 (0.65; 1.19)	0.410
Number of prior psychiatric hospitalizations (none)	0.94 (0.72; 1.22)	0.639	1.38 (0.91; 2.09)	0.127
Duration of prior hospitalizations (≤30 days)	0.88 (0.65; 1.18)	0.394	1.09 (0.71; 1.66)	0.699

Abbreviations: BMI, body mass index; CI, confidence interval; USA, United States of America.