Insufficient Knowledge and Vaccination Practice of Inflammatory Bowel Disease Patients in the People's Republic of China

Figures & data

Table 1 Participant Characteristics

Participant Characteristics	N=900	%
Gender
Male	534	59.3
Female	366	40.7
Age
<28	303	33.7
[28–37]	288	32.0
≥38	309	34.3
Education
≤high school diploma	391	43.4
>high school diploma	509	56.6
Disease classification
Ulcerative colitis	189	21
Crohn’s Disease	693	77
Unclassified	18	2
Registered residents
Rural	415	46.1
Urban	485	53.9
Diagnosis time, years
<1	151	16.8
[1–2]	185	20.6
[2–5]	321	35.7
[5–10]	159	17.7
[10–15]	70	7.8
[15–19]	9	1
≥20	5	0.6
Immunosuppressive treatment	746	82.9
Systemic corticosteroids	342/746	54.2
Immunomodulators	464/746	37.8
Biological therapies	537/746	28
Treatment duration, years
<1	196/746	26.3
[1–2]	177/746	23.7
[2–5]	236/746	31.6
[5–10]	97/746	13.0
[10–15]	27/746	3.6
[15–19]	5/746	0.7
≥20	1/746	0.1
Not clear	7/746	0.9
CCCF volunteers
Yes	167	18.6
No	733	81.4

Table 2 Multivariate Analysis of Factors Associated with Patient’s Knowledge of Recommended Vaccination

Factor	OR(95%Cl)	p-value
Age		0.004
>37	1
[28–37]	1.01 [0.64–1.61]	0.957
<28	1.81 [1.19–2.76]	0.006
Sex		0.195
Male	1
Female	0.79 [0.56–1.13]
Education		0.671
≤high school diploma	1
>high school diploma	0.93 [0.65–1.32]
Disease classification		0.026
Ulcerative colitis	1
Crohn’s disease	1.74 [1.07–2.83]
CCCF volunteers		0.501
No	1
Yes	1.16 [0.76–1.76]

Note: The bold figures are significant factors.

Abbreviation: OR, odds ratio.

Table 3 Multivariate Analysis of Factors Associated with Patient’s Knowledge of Contraindicated Vaccines

Factor	OR(95%Cl)	p-value
Age		0.734
>37
[28–37]	0.97 [0.58–1.62]	0.899
<28	1.15 [0.71–1.89]	0.569
Sex		0.456
Male	1
Female	0.86 [0.57–1.29]
Education		0.109
≤high school diploma	1
>high school diploma	1.42 [0.92–2.17]
Disease classification		0.013
Ulcerative colitis	1
Crohn’s Disease	2.18 [1.18–4.04]
CCCF volunteers		0.001
No	1
Yes	2.04 [1.31–3.16]

Note: The bold figures are significant factors.

Abbreviation: OR, odds ratio.

Figure 1 Sources of IBD-related vaccination knowledge.

Table 4 Multivariate Analysis of Factors Associated with Notification Rate at Patients’ Initial Immunosuppressive Treatment

Factor	OR(95%Cl)	p-value
Drugs used for the first immunosuppressive therapy
Systemic corticosteroids		0.990
No	1
Yes	1.00 [0.63–1.6]
Immunomodulators		0.323
No	1
Yes	1.23 [0.81–1.86]
Biological therapies		0.003
No	1
Yes	2.07 [1.27–3.38]
Doctors using immunosuppressive treatment for the first time		0.001
IBD specialist	1
Other physicians	0.38 [0.22–0.66]
Time since first used immunosuppressive therapy, years		<0.001
<2	1
[2–5]	0.94 [0.62–1.43]	0.784
>5	0.26 [0.15–0.46]	<0.001

Note: The bold figures are significant factors.

Abbreviation: OR, odds ratio.

Table 5 Multivariate Analysis of Factors Associated with Hepatitis B Vaccination

Factor	OR(95%Cl)	p-value
Age		0.430
<28	1
[28–37]	1.13 [0.64–1.97]	0.680
≥38	0.74 [0.4–1.39]	0.354
Sex		0.348
Male	1
Female	1.26 [0.77–2.06]
Disease classification		0.353
Ulcerative colitis	1
Crohn’s Disease	1.4 [0.69–2.82]
Diagnosis time, years		0.001
<2	1
[2–5]	0.33 [0.18–0.61]	<0.001
>5	0.77[0.42–1.41]	0.394
Have doctors informed you about vaccination?		<0.001
No	1
Yes	4.61 [2.73–7.76]
Knowledge of susceptibility		0.620
Not understand	1
Understand	1.13 [0.69–1.86]
Attitudes towards hepatitis B vaccine effectiveness		0.178
Not clear or ineffective	1
Effective	1.79 [0.77–4.18]
Attitudes towards hepatitis B vaccine safety		0.034
Unsafe	1
Safe	2.68[1.08–6.65]

Note: The bold figures are significant factors.

Abbreviation: OR, odds ratio.

Table 6 Multivariate Analysis of Factors Associated with Varicella Vaccination

Factor	OR(95%Cl)	p-value
Age		0.055
<28	1
[28–37]	0.45 [0.2–1.02]	0.055
≥38	0.37 [0.14–1]	0.0497
Sex		0.675
Male	1
Female	1.17 [0.56–2.42]
Disease classification		0.346
Ulcerative colitis	1
Crohn’s disease	0.61 [0.21–1.71]
Diagnosis time, years		0.014
<2	1
[2–5]	0.37 [0.16–0.87]	0.022
>5	0.25 [0.08–0.8]	0.020
Have doctors informed you about vaccination?		<0.001
No	1
Yes	4.93 [2.02–12.05]
Knowledge of susceptibility		0.146
Not understand	1
Understand	0.59 [0.29–1.2]
Attitudes towards hepatitis B vaccine effectiveness		0.487
Not clear or ineffective	1
Effective	1.56 [0.45–5.46]
Attitudes towards hepatitis B vaccine safety		0.071
Unsafe	1
Safe	4.07 0.89–18.65]

Note: The bold figures are significant factors.

Abbreviation: OR, odds ratio.