Noninvasive brain stimulation by radioelectric asymmetric conveyor in the treatment of agoraphobia: open-label, naturalistic study

Figures & data

Table 1 Agoraphobia Scale items

Item	Description
1	Being alone in your home
2	Shopping unaccompanied in small shops (eg, a grocery, pharmacy, etc)
3	Crossing a street in the city alone
4	Being in a crowd unaccompanied
5	Traveling on a bus unaccompanied, when it is crowded
6	Walking straight across large open spaces in the city (eg, a square)
7	Driving a car alone through a long tunnel
8	Walking away from your home alone
9	Traveling by train or underground unaccompanied, when it is crowded
10	Standing unaccompanied in a long queue in a post office, bank, supermarket, etc
11	Sitting on a chair for a long time, when in the company of other people
12	Eating at a restaurant or café
13	Sitting in the middle of a row at a cinema or theater
14	Shopping unaccompanied in a department store that is full of people
15	Walking over a bridge when there are a lot of people and traffic about
16	Driving a car alone over a bridge
17	Having a haircut at the hairdresser, unaccompanied
18	Shopping unaccompanied in a large supermarket, crowded with people
19	Walking in a crowded street unaccompanied
20	Riding in an elevator unaccompanied

Table 2 Agoraphobia Scale: anxiety

Item	Average change (%)			Statistical test
				Wilcoxon Z; Asymp Sig			Sign test Exact Sig
	t1–t0	t2–t0	t2–t1	t1–t0	t2–t0	t2–t1	t1–t0	t2–t0	t2–t1
Significant response to treatment
1	64.10	74.36	28.57	−4.28; 0.000	−4.33; 0.000	−4.28; 0.000	0.000	0.000	0.008
2	22.37	72.37	64.41	−3.69; 0.000	−4.33; 0.000	−3.69; 0.000	0.000	0.000	0.000
3	66.67	74.36	23.08	−4.28; 0.000	−4.33; 0.000	−4.28; 0.034	0.000	0.000	0.063
4	22.37	72.37	64.41	−3.37; 0.001	−4.33; 0.000	−3.37; 0.000	0.001	0.000	0.000
5	22.37	73.68	66.10	−3.49; 0.000	−4.33; 0.000	−3.49 0.000	0.000	0.000	0.000
6	21.33	72.00	64.41	−2.96; 0.003	−4.29; 0.000	−2.96; 0.000	0.003	0.000	0.000
8	21.33	72.00	64.41	−3.02; 0.000	−4.32; 0.000	−4.32; 0.000	0.001	0.000	0.000
9	22.37	73.68	66.10	−3.49; 0.000	−4.31; 0.000	−4.39; 0.000	0.000	0.000	0.000
11	22.37	73.68	66.10	−3.49; 0.000	−4.33; 0.000	−4.34; 0.000	0.000	0.000	0.000
12	22.37	72.37	64.41	−3.69; 0.000	−4.36; 0.000	−4.32; 0.000	0.000	0.000	0.000
14	23.38	72.73	64.41	−3.22; 0.001	−4.31; 0.000	−4.32; 0.000	0.001	0.000	0.000
15	22.37	73.68	66.10	−3.49; 0.000	−4.33; 0.000	−4.34; 0.000	0.000	0.000	0.000
16	25.32	73.42	64.41	−3.54; 0.000	−4.33; 0.000	−4.32; 0.000	0.000	0.000	0.000
17	22.37	73.68	66.10	−3.54; 0.000	−4.27; 0.000	−4.39; 0.000	0.000	0.000	0.000
18	22.37	72.37	64.41	−3.22; 0.001	−4.27; 0.000	−4.32; 0.000	0.001	0.000	0.000
19	36.84	73.68	58.33	−4.32; 0.000	−4.33; 0.000	−4.46; 0.000	0.000	0.000	0.000
20	55.26	72.37	38.24	−4.17; 0.000	−4.27; 0.000	−3.36; 0.001	0.000	0.000	0.000
Moderate response to treatment
10	22.37	72.37	64.41	−2.76; 0.006	−3.36; 0.001	−2.00; 0.046	0.004	0.000	0.125
13	66.67	74.36	23.08	−3.22; 0.001	−3.46; 0.001	−2.24; 0.025	0.001	0.000	0.063
Low response to treatment
7	1.28	2.56	1.30	−1.00; 0.317	−1.41; 0.157	−1.00; 0.317	NR*	0.500	NR*

* Note: Sign test algorithm gave no response value in this instable case.

Abbreviations: Asymp Sig, asymptotic significance (two-tailed); Exact Sig, exact significance (two-tailed); NR, no response.

Table 3 Agoraphobia Scale: avoidance

Item	Average change (%)			Statistical test
				Wilcoxon Z; Asymp Sig			Sign test Exact Sig
	t1–t0	t2–t0	t2–t1	t1–t0	t2–t0	t2–t1	t1–t0	t2–t0	t2–t1
Significant response to treatment
1	64.10	74.36	28.57	−4.28; 0.000	−4.33; 0.000	−4.28; 0.000	0.000	0.000	0.008
2	22.37	72.37	64.41	−3.69; 0.000	−4.33; 0.000	−3.69; 0.000	0.000	0.000	0.000
3	66.67	74.36	23.08	−4.28; 0.000	−4.33; 0.000	−4.28; 0.034	0.000	0.000	0.063
4	22.37	72.37	64.41	−3.37; 0.001	−4.33; 0.000	−3.37; 0.000	0.001	0.000	0.000
5	22.37	73.68	66.10	−3.49; 0.000	−4.33; 0.000	−3.49 0.000	0.000	0.000	0.000
6	21.33	72.00	64.41	−2.96; 0.003	−4.29; 0.000	−2.96; 0.000	0.003	0.000	0.000
8	21.33	72.00	64.41	−3.02; 0.000	−4.32; 0.000	−4.32; 0.000	0.001	0.000	0.000
9	22.37	73.68	66.10	−3.49; 0.000	−4.31; 0.000	−4.39; 0.000	0.000	0.000	0.000
11	22.37	73.68	66.10	−3.49; 0.000	−4.33; 0.000	−4.34; 0.000	0.000	0.000	0.000
12	22.37	72.37	64.41	−3.69; 0.000	−4.36; 0.000	−4.32; 0.000	0.000	0.000	0.000
14	23.38	72.73	64.41	−3.22; 0.001	−4.31; 0.000	−4.32; 0.000	0.001	0.000	0.000
15	22.37	73.68	66.10	−3.49; 0.000	−4.33; 0.000	−4.34; 0.000	0.000	0.000	0.000
16	25.32	73.42	64.41	−3.54; 0.000	−4.33; 0.000	−4.32; 0.000	0.000	0.000	0.000
17	22.37	73.68	66.10	−3.54; 0.000	−4.27; 0.000	−4.39; 0.000	0.000	0.000	0.000
18	22.37	72.37	64.41	−3.22; 0.001	−4.27; 0.000	−4.32; 0.000	0.001	0.000	0.000
19	36.84	73.68	58.33	−4.32; 0.000	−4.33; 0.000	−4.46; 0.000	0.000	0.000	0.000
20	55.26	72.37	38.24	−4.17; 0.000	−4.27; 0.000	−3.36; 0.001	0.000	0.000	0.000
Moderate response to treatment
10	22.37	72.37	64.41	−2.76; 0.006	−3.36; 0.001	−2.00; 0.046	0.004	0.000	0.125
13	66.67	74.36	23.08	−3.22; 0.001	−3.46; 0.001	−2.24; 0.025	0.001	0.000	0.063
Low response to treatment
7	1.28	2.56	1.30	−1.00; 0.317	−1.41; 0.157	−1.00; 0.317	NR*	0.500	NR*

* Note: Sign test algorithm gave no response value in this instable case.

Abbreviations: Asymp Sig, asymptotic significance (two-tailed); Exact Sig, exact significance (two-tailed); NR, no response.