Quality of Life of Drug Reaction with Eosinophilia and Systemic Symptom (DRESS) and Stevens-Johnson Syndrome (SJS) and/or Toxic Epidermal Necrolysis (TEN) Patients

Figures & data

Table 1 Clinical and Demographic Characteristics of DRESS, SJS, and SJS/TEN Patients

Characteristics	DRESS (%) N = 21	SJS (%) N = 32	SJS/TEN (%) N = 5
Gender
Male	8 (38)	17 (53)	2 (40)
Female	13 (62)	21 (65)	3 (60)
Age (Mean±SD)	38,8 ± 10.97	33,3 ±17,20	34 ±13
IQR, p value: 0.521	16.00	27.00	28.50
Hospitalization duration	10,5 ± 6.70	11,6 ± 5.60	12 ± 2.90
IQR, p value: 0.749	13.50	12.75	5.50
Causative Agent (ATC Classification)
Antibiotic (J01CA04)	14 (67)	18 (56)	4 (80)
NSAIDs (M01A)	5 (24)	6 (18)	1 (20)
OAT (J04A)	3 (14)	2 (6)	0 (0)
ARV (J05A)	1 (5)	4 (12.5)	1 (20)
Anti-convulsant (N03AA)	3 (14)	14 (44)	1 (20)
Other	0 (0)	16 (50)	3 (60)

Abbreviations: NSAIDs, non-steroidal anti-inflammatory drugs; OAT, anti-tuberculosis drug; ARVs, antivirals; other drugs, such as allopurinol, paracetamol, domperidone, ambroxol, tramadol, diazepam, and bromhexine.

Table 2 Overview of Inpatient Treatment of DRESS, SJS, and SJS/TEN

Drug Therapy	The Number of Patient (%)
	DRESS (N = 21)	SJS (N = 32)	SJS/TEN (N = 5)
Supportive Therapy (ATC Classification)
Acid-related disorder drugs (A02)		20 (63)	5 (100)
Antihistamines (R06)		22 (69)	4 (80)
Analgesic (N02)		21 (66)	4 (80)
Fluid and electrolyte therapy (B05XA)		32 (100)	5 (100)
Antithrombotic agents (B01)	21 (100)	5 (16)	2 (7)
Antibiotic (J01CA04)		16 (50)	5 (100)
Specific Therapy
Corticosteroid injection (H02)	19 (90)	31 (96)	5 (100)
Corticosteroid oral (H02))	19 (90)	29 (90)	3 (60)
Cyclosporine + corticosteroid (L40D01+ H02)		1 (3)	0 (0)
Topical Therapy
Eye medications (corticosteroids D07)	5 (24)	8 (25)	0 (0)
Eye medications (Antibiotics D06A)		20 (63)	3 (60)
Eye medications (Eomlien and protectives D03A)	14 (67)	25 (78)	4 (80)
Skin medications (corticosteroids D07)		3 (9)	1 (20)
Skin medications (antibiotics D06A)		26 (81)	4 (80)
Skin medications (emollients D02A)		15 (47)	3 (60)
Skin medications (antiseptic/silver sulfadiazine D08AL)		20 (63)	3 (60)
Mouthwash (antiseptic D08AG)		8 (25)	1 (20)

Table 3 The Mean Score of Utility and VAS in DRESS, SJS and SJS/TEN Patients

Patients	n	Utility Mean, IQR	SD	p value
DRESS	21	0.61, 0.44	0.23	0.001*
SJS	32	0.08, 0.65	0.42
SJS/TEN	5	0.03, 1.08	0.01
		VAS Mean, IQR	SD	p value
DRESS	21	73.36, 26.25	14.48	0.008*
SJS	32	57.93, 32.50	26.37
SJS/TEN	5	50.00, 55.00	24.35

Note: *Significant difference (normally distributed data), One way Anova test.

Table 4 Health Profiles of DRESS, SJS and SJS/TEN Patients Based on EQ-5D-5L

Dimensions		DRESS (%)	SJS (%)	SJS/TEN (%)
Mobility	No problem	36.4	10.3	20.0
	Slight problem	31.8	34.5	40.0
	Moderate problem	31.8	31.0	0
	Severe problem	0	13.8	20.0
	Unable to do	0	10.3	20.0
Self care	No problem	40.9	3.4	0
	Slight problem	27.3	44.8	0
	Moderate problem	31.8	17.2	20.0
	Severe problem	0	17.2	40.0
	Unable to do	0	17.2	40.0
Usual activities	No problem	50.0	0	20.0
	Slight problem	31.8	31.0	0
	Moderate problem	18.2	34.5	20.0
	Severe problem	0	20.7	20.0
	Unable to do	0	13.8	40.0
Pain/Discomfort	No problem	9.1	3.4	0
	Slight problem	40.9	13.8	0
	Moderate problem	45.5	24.1	40.0
	Severe problem	4.5	44.8	40.0
	Unable to do	0	13.8	20.0
Anxiety/Depression	No problem	40.9	6.9	40.0
	Slight problem	18.2	10.3	0
	Moderate problem	40.9	31.0	20.0
	Severe problem	0	44.8	40.0
	Unable to do	0	6.9	0

Table 5 VAS Profile of DRESS, SJS and SJS/TEN Patients Based on EQ-5D-5L

VAS Score	DRESS (%)	SJS (%)	SJS/TEN (%)
The best health	9.1	3.4	0
The worst health	0	10.3	0