Patient adherence issues in the treatment of hepatitis C

Figures & data

Figure 1 Organization of TE.

Abbreviations: HRQOL, health-related quality of life; TE, therapeutic education.

Table 1 Studies assessing the efficacy of TE in the treatment of HCV infection

Study	Study type	Number of patients in TE/control group	HCV genotype and treatment experience	Results: adherence with TE versus in control group	Results: sustained virological response with TE versus in control group
PEGOBS protocol^Citation15,Citation72	Multicentric, controlled, randomized study; TE by nurses	123/121	All genotypes; naïve responders/nonresponders to a previous treatment	74.0% vs 62.8%; P=0.06 Expert-center 83.1% vs 61.9%; P=0.007	38.2% vs 24.8%; P=0.02 Expert-center 47.7% vs 23.8%; P=0.004
CHEOPS study^Citation68	Prospective, observational, nonstandardized study; TE	370/304	Genotype HCV 2/3; naïve responders/nonresponders to a previous treatment	61% vs 47%; P=0.001	77% vs 70% (TE); P=0.05
Renou et al^Citation69	Controlled, nonrandomized study; TE by nurses	98/326	All genotypes; naïve responders/nonresponders to previous treatment	–	71.4% vs 53.3%; P=0.001
Bernard-Leclerc et al^Citation70	Monocentric, prospective, uncontrolled, nonrandomized observational study; TE by nurses	17	All genotypes: naïve responders/nonresponders	90.6%	12/17 (70.5%)

Abbreviations: HCV, hepatitis C virus; TE, therapeutic education; vs, versus.

LarreyDSalseARibardDHepatitis C Network of Languedoc Roussillon (France). Education by a nurse increases response of patients with chronic hepatitis C to therapy with peginterferon-α2a and ribavirinClin Gastroenterol Hepatol2011978178521683161

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LarreyDUn exemple d’éducation thérapeutique par un infirmière sur l’observance et l’efficacité du traitement par bithérapie peginterferon-alpha2-ribavirine dans l’hépatite chronique C: protocole PEGOBS [An example of therapeutic education by a nurse on compliance and efficacy of treatment with bitherapy peginterferon-alpha2-ribavirin in chronic hepatitis C: PEGOBS protocol]Bull Epidemiol Hebd20122930350354 French

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CacoubPOuzanDMelinPPatient education improves adherence to peg-interferon and ribavirin in chronic genotype 2 or 3 hepatitis C virus infection: a prospective, real-life, observational studyWorld J Gastroenterol2008146195620318985810

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RenouCLahmekPParienteAImpact of therapeutic education on the outcome of chronic hepatitis C treatmentHepatology2009729A (abstract)

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Bernard-LeclercJConortOBacqYAntierDImpact d’un programme d’éducation thérapeutique sur les connaissances, l’observance et la satisfaction des patients traités pour hépatite chronique virale C [Impact of a therapeutic education program on the knowledge, the adherence and the satisfaction of the patients treated for viral chronic hepatitis C]Ther Patient Educ201132133

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