Treatment Satisfaction and Its Associated Factors of Dolutegravir Based Regimen in a Resource Limited Setting

Figures & data

Table 1 Descriptive Statistics of Socio-Demographic Characteristics of HIV Patients on Dolutegravir Based Regimen at Debre Markos Referral Hospital 2020

Variable	N	%	Variable	N	%
Age			Monthly Income
19–31	94	26.9	<800	71	20.3
32–44	129	37.0	800–1600	95	27.2
45–57	102	29.2	1600–3500	85	24.4
58–70	19	5.4	≥3500	98	28.1
71–83	5	1.4	Marital status
Sex			Single	64	18.3
Female	192	55.0	Married	155	44.4
Male	157	45.0	Divorced	65	18.6
Residency			Widowed	65	18.6
Urban	297	85.1	Educational status
Rural	52	14.9	No formal education	70	20.1
			Primary school Education	109	31.2
			Secondary school education	95	27.2
Occupational status			Diploma and above	75	21.5
Unemployed	62	17.8	Religion
Governmental	109	31.2	Orthodox	228	65.3
jobs	178	51.0	Muslim	118	33.8
Private jobs			Protestant	3	0.9

Table 2 Descriptive Statistics of Clinical Characteristics and Knowledge of HIV Patients on Dolutegravir Based Regimen at Debre Markos Referral Hospital 2020

	N	%	Self-Rated Health Status	N	%
Beliefs about medications			Poor	9	2.6
Positive belief	182	52.1	Fair	154	44.1
Negative belief	167	47.9	Good	178	51.0
Knowledge about medications			Excellent	8	2.3
Good	266	76.22	Concurrent medications with DTG	N =37
Poor	83	23.78	Isoniazid	7	18.9
Comorbidity			Hydrochlorothiazide	8	21.6
None	312	89.4	Nifedipine	4	10.8
Hypertension	14	4	Metformin	4	10.8
Tuberculosis	7	2	Insulin	3	8.1
Diabetes	7	2	Others***	11	29.8
Meningitis	2	0.6
Others**	7	2

Notes: **Pneumonia, PUD, toxoplasmosis, PCP, oral candidiasis. ***Others: amoxicillin and clavulanate potassium, metronidazole, tramadol, cotrimoxazole, cimetidine, omeprazole, fluconazole, pyridoxine, enalapril, ceftriaxone.

Table 3 Factors Associated with Treatment Satisfaction of Dolutegravir Based Regimen at DRH 2020

Independent Variable	Treatment Satisfaction		COR(CI)	P-value	AOR(CI)	P-value
Gender	High	Low		<0.001		0.017*
Male	131	26	3.37(2.03, 5.62)		2.10 (1.14, 3.87)
Female	115	77	1		1
Occupation Type				0.053		0.084
Governmental job	68	41	0.73(0.38, 1.42)	0.359	0.44 (0.18, 1.05)	0.065
Privet job	135	43	1.39(0.73, 2.63)	0.190	0.83 (0.39, 1.80)	0.643
Unemployed	43	19	1		1
Do you discuss about the treatment change?
Yes	114	21	3.37(1.96, 5.79)	<0.001	3.03 (1.58, 5.88)	0.001*
No	132	82	1		1
Monthly income						0.039*
<800	41	30	1	0.065	1
800–1600	72	23	2.29(1.18, 4.45)	0.015	2.88 (1.26, 6.58)	0.012*
1600–2500	63	22	2.10(1.07, 4.12)	0.032	2.47 (1.11, 5.48)	0.026*
≥3500	70	28	1.83(0.96, 3.48)	0.066	3.11 (1.31, 7.37)	0.010*
Beliefs about medication
Positive belief	146	36	2.72(1.68, 4.38)	<0.001	3.05(1.76, 5.28)	0.0001*
Negative belief	100	67	1		1
Concurrent medications
No	232	80	4.76(2.34, 9.70)	<0.001	7.72 (3.29, 18.07)	0.0001*
Yes	14	23	1		1

Note: *Significant at p<0.05.