Validation of the Spanish Version of the VERITAS-PRN Scale to Assess Adherence to on Demand Regimens in Patients with Hemophilia

Figures & data

Table 1 Sociodemographic and Clinical Characteristics of the Patients

	n	%	M	SD	R
Age			44.1	10.7	[15–64]
Body Mass Index			26.4	3.3	[17–38]
Type of Hemophilia
Hemophilia A	68	80.0
Hemophilia B	17	20.0
Severity of Hemophilia
Mild	9	10.6
Moderate	39	45.9
Severe	37	43.5
Development of inhibitors
Yes	4	4.7
No	81	95.3
Dose^a (patients without inhibitors)			2423.6	603.15	[1000–4000]
Dose^b (patients with inhibitors)			5.75	0.95	[5.0–7.0]
Port-a-cat background data
Yes	2	2.4
No	83	97.6
Family history of Hemophilia
Yes	56	65.9
No	29	34.1
Hemarthrosis in the previous month
Yes	48	56.5
No	37	43.5
Number of hemarthrosis			1.3	1.8	[0–8]
Arthropathy
Yes	73	85.9
No	12	14.1
Orthoses
Yes	13	15.3
No	72	84.7
Co-infections
Yes	46	51.8
No	39	45.9

Notes: Dose^a: dosing clotting concentrates (international units); Dose^b: bypass agent dosing (Bethesda units).

Abbreviations: n, sample size; %, percent; M, mean; SD, standard deviation; R, range.

Table 2 Descriptive Statistics of VERITAS-PRN in the Spanish Sample

	M	SD	Floor Effect (%)	Ceiling Effect (%)	Min	Max
Total	40.2	9.0	12	0	24	72
Treatment	6.0	2.6	27.1	1.2	4	20
Time	6.4	3.2	49.4	0	4	16
Dose	6.1	1.7	23.5	0	4	10
Plan	6.3	2.8	22.4	1.2	4	20
Remember	5.1	1.6	51.8	0	4	12
Communicate	10.3	3.0	47	0	4	16

Abbreviations: M, mean; SD, standard deviation; Min, minimum score; Max, maximum score.

Table 3 Descriptive Statistics and Homogeneity Index of the Items of VERITAS-PRN

Items	M	SD	Sk	Ku	IH
Treatment
I1	1.45	1.01	2.54	5.83	0.73
I2	1.68	0.83	2.18	6.97	0.56
I3	1.49	0.76	2.45	8.72	0.42
I4	1.31	0.63	2.99	12.78	0.36
Time
I5	1.53	0.93	1.81	3.03	0.61
I6	4.31	1.17	−1.69	1.82	0.34
I7	4.64	0.84	−2.80	8.20	0.22
I8	1.77	1.18	1.47	1.05	0.57
Dose
I9	1.31	0.60	3.13	15.69	0.32
I10	1.11	0.42	4.77	27.66	0.37
I11	1.34	0.68	2.87	10.99	0.35
I12	3.69	1.20	−0.56	−0.72	−0.04
Plan
I13	3.97	1.05	−1.59	2.43	0.10
I14	1.46	0.86	2.77	8.69	0.57
I15	1.51	0.94	2.62	7.18	0.65
I16	1.28	0.85	3.58	12.64	0.49
Remember
I17	4.77	0.59	−3.85	20.03	0.38
I18	1.36	0.98	3.14	9.13	0.43
I19	4.83	0.38	−1.77	1.14	0.18
I20	4.71	0.48	−1.28	0.41	0.17
Communicate
I21	3.05	1.08	−0.21	−0.82	0.13
I22	3.00	1.24	0.00	−1.01	0.27
I23	3.20	1.07	0.26	−0.94	−0.08
I24	1.39	0.80	2.55	6.93	0.37

Abbreviations: M, mean; SD, standard deviation; Sk, skewness; Ku, kurtosis; IH, homogeneity index; α, alpha coefficient.

Table 4 Mean, Standard Deviation of the Total Score in Each Category of VERITAS-PRN

Categories	1	2	3	4	5
Item	M(SD)	M(SD)	M(SD)	M(SD)	M(SD)
Treatment
I1	36.7(5.5)	45.4(6.1)	51.3(2.1)	47.5(0.7)	67.3(3.7)
I2	37.2(8.6)	40.2(5.2)	51.5(0.7)	–	68.7(2.9)
I3	38.5(8.9)	40.3(5.2)	51.5(0.7)	–	69.5(3.5)
I4	38.6(8.3)	42.8(8.5)	51.5(0.7)	–	67.0(–)
Time
I5	36.7(5.6)	44.9(9.9)	47.6(8.3)	–	61.5(6.4)
I6	37.2(7.3)	44.0(9.1)	47.3(5.3)	44.3(8.6)	50.2(14.6)
I7	37.9(7.7)	52.0(8.4)	43.4(8.8)	51.0(–)	42.0(1.4)
I8	35.9(5.4)	41.6(4.8)	52.1(12.3)	46.3(5.3)	57.3(13.3)
Dose
I9	38.9(9.0)	42.1(5.7)	–	–	72.0(–)
I10	39.2(8.2)	47.4(9.8)	–	67.0(–)	–
I11	38.2(7.7)	43.9(9.5)	52.0(–)	67.0(–)	48.0(–)
I12	38.8(13.3)	41.4(8.4)	39.1(3.6)	42.9(3.7)	40.3(4.1)
Plan
I13	39.8(12.8)	38.9(5.7)	42.5(6.8)	51.0(15.1)	44.8(7.7)
I14	37.1(6.8)	43.5(7.5)	–	67.0(–)	61.0(7.2)
I15	37.1(6.6)	42.0(5.5)	–	67.0(–)	63.8(8.1)
I16	38.0(6.5)	51.9(12.9)	47.0(–)	46.0(–)	61.0(7.2)
Remember
I17	38.5(8.1)	46.9(7.9)	37.0(–)	–	67.0(–)
I18	37.9(6.5)	47.0(10.1)	63.0(–)	–	54.2(14.1)
I19	29.3(8.9)	44.4(8.2)	–	–	–
I20	38.8(8.4)	44.0(9.8)	36.0(–)	–	–
Communicate
I21	39.4(15.2)	36.1(9.6)	40.1(6.6)	42.7(8.4)	43.2(3.1)
I22	34.6(11.7)	37.4(6.9)	40.5(8.5)	41.9(7.3)	47.2(9.2)
I23	40.9(14.2)	40.4(12.3)	38.3(4.7)	40.8(5.8)	49.5(4.9)
I24	38.0(7.7)	43.4(7.5)	50.0(1.4)	60.7(12.7)	38.0(–)

Abbreviations: M, mean; SD, standard deviation; r_jx, discrimination index; α, alpha coefficient.

Table 5 Reliability Coefficients of Scores of the VERITAS-PRN in Spain and USA

Items	Spain		USA
	Alpha		Pearson	Alpha
	Test	Retest	Test–Retest	Test
Treatment	0.78	0.68	0.93	0.78
Time	0.76	0.85	0.96	0.76
Dose	0.22	0.35	0.95	0.63
Plan	0.42	0.71	0.94	0.8
Remember	0.66	0.49	0.94	0.66
Communicate	0.80	0.60	0.91	0.80
Total	0.85	0.80	0.94	0.85

Table 6 Mean (SD) of the Dimensions of VERITAS-PRN

	(1)	(2)	(3)	(4)	(5)	(6)	(7)
Type of Hemophilia
Hemophilia A	6.0(2.8)	6.3(3.2)	6.2(1.8)	6.3(2.6)	5.2(1.6)	10.6(2.9)	40.4(9.6)
Hemophilia B	5.9(0.9)	6.7(3.3)	6.0(1.4)	6.6(3.8)	4.8(1.5)	9.1(2.9)	39.(5.9)
Severity
Low	9.4(5.6)***	10.3(3.3)***	6.3(1.9)	5.5(1.4)***	6.2(1.9)	10.3(3.1)	52.0(13.1)***
Moderate	5.5(1.8)	5.2(2.6)	6.1(1.8)	6.4(3.2)	4.8(1.5)	10.3(2.9)	38.2(7.8)
Severe	5.7(1.3)	6.7(2.9)	6.1(1.6)	5.5(1.4)	5.1(1.5)	10.3(3.1)	39.4(6.9)
Inhibitors
Yes	6.8(2.5)	8.8(3.4)	5.0(0.8)	5.5(1.9)	6.3(2.9)	9.8(4.3)	42.0(12.5)
No	5.9(2.6)	6.3(3.1)	6.2(1.7)	6.4(2.9)	5.0(1.5)	10.3(2.9)	40.1(8.9)
Hemarthrosis
Yes	5.8(1.7)	6.5(3.0)	6.0(1.7)	5.6(1.6)*	4.9(1.3)	10.6(3.2)	29.4(7.2)
No	6.2(3.4)	6.2(3.5)	6.3(1.8)	7.2(3.8)	5.2(1.8)	9.9(2.7)	41.2(10.9)
Arthropathy
Yes	5.4(1.2)***	5.6(2.6)***	6.1(1.7)	5.6(1.5)	4.9(1.3)	10.2(2.9)	37.7(6.2)***
No	9.6(4.9)	11.2(2.2)	6.4(2.0)	10.4(5.1)	6.4(2.5)	11.0(3.4)	55.0(9.5)
Infections
Yes	5.7(2.3)	6.1(3.2)	6.4(1.8)	6.5(2.8)	4.5(1.1)**	10.3(3.4)	39.4(8.4)
No	6.2(2.8)	6.7(3.2)	5.9(1.6)	6.2(2.9)	5.5(1.8)	10.3(2.6)	40.9(9.5)
Orthoses
Yes	5.2(1.3)	6.5(3.0)	5.7(1.7)	5.2(1.5)	5.0(1.4)	9.2(3.2)	38.7(8.7)
No	6.1(2.7)	6.4(3.2)	6.2(1.7)	6.5(3.0)	5.1(1.6)	10.5(2.9)	40.8(9.0)

Notes: (1) Treatment; (2) time; (3) dose; (4) plan; (5) remember; (6) communicate; (7) total. *p < 0.05; **p < 0.01; ***p < 0.001.