Predictive Value of Troponin I, Creatinine Kinase Isoenzyme and the New Japanese Severity Score in Severe Acute Pancreatitis

Figures & data

Table 1 Results of Univariate Analysis of SACI (n=136)

Variable	Constituencies		Statistics	P
	Non-SACI(n=102)	SACI(n=34)
Age(year)	44.00(36.00, 57.25)	45.50(35.00, 66.25)	−0.128^a	0.898
Gender
Female	31(81.58%)	7(18.42%)	1.217^c	0.270
Male	71(72.45%)	27(27.55%)
New JSS	3.00(2.00, 4.00)	4.00(3.00, 6.00)	−2.062^b	0.039
Temperature(°C)	36.50(36.30, 37.00)	36.70(36.28, 37.25)	−0.672^b	0.501
Heart Rate(HR)	97.38±23.53	99.82±20.03	−0.543^a	0.588
Respiratory Rate(RR)	22.00(18.75, 25.00)	24.50(20.75, 26.50)	−2.635^b	0.008
SBP(mmHg)	137.58±21.19	142.94±22.22	−1.263^a	0.209
DBP(mmHg)	88.00(78.00, 97.00)	90.50(76.75, 103.25)	−0.704^b	0.482
Alcohol	34(75.56%)	11(24.44%)	0.011^c	0.916
Smoke	40(72.73%)	15(27.27%)	0.254^c	0.614
Hypertension	25(69.44%)	11(30.56%)	0.806^c	0.369
Hyperlipidemia	8(88.89%)	1(11.11%)	0.992^c	0.319
WBC(×10^9/L)	13.54±4.74	15.65±4.49	2.268^a	0.025
Platelet(×10^9/L)	223.07±85.32	188.09±77.86	2.112^a	0.037
D-Dimer(mg/L)	1.94(0.73, 4.83)	2.52(0.56, 5.17)	−0.159^b	0.874
Prothrombin Time(s)	12.30(11.10, 13.60)	12.40(11.00, 14.10)	−0.415^b	0.678
APTT(s)	27.00(23.05, 30.15)	28.80(25.90, 37.80)	−2.230^b	0.026
Thrombin Time(s)	17.90(16.40, 19.70)	18.10(16.70, 21.50)	−0.788^b	0.431
Fibrinogen(g/L)	4.45±1.92	3.83±2.32	1.490^a	0.139
Troponin I(ng/mL)	0.01(0.01, 0.03)	0.05(0.04, 0.30)	−9.036^b	0.000
Blood Glucose(mmol/L)	9.52(7.30, 12.98)	9.43(7.03, 14.46)	−0.168^b	0.867
Amylase(U/L)	404.05(145.73, 932.60)	497.90(142.05, 1015.85)	−0.318^b	0.751
HDL(mmol/L)	1.21(0.84, 2.04)	1.19(0.90, 3.69)	−0.440^b	0.660
LDL(mmol/L)	2.62±1.43	2.29±1.91	1.055^a	0.293
C-reactive protein(mg/L)	113.40(36.00, 168.35)	42.00(6.88, 132.38)	−1.734^b	0.083
Lactate Dehydrogenase(U/L)	300.10(232.50, 413.90)	309.95(226.58, 633.35)	−0.841^b	0.400
Serum Calcium(mmol/L)	2.09±0.26	2.12±0.32	−0.568^a	0.571
Triglyceride(mmol/L)	5.49(1.14, 18.16)	4.09(1.09, 20.67)	−0.366^b	0.714
Creatine Kinase Isoenzyme(ng/mL)	3.52(1.75, 15.40)	8.41(4.49, 30.15)	−2.551^b	0.011
Total Cholesterol(mmol/L)	5.81(4.21, 11.92)	5.17(3.59, 12.62)	−0.781^b	0.435
Procalcitonin(ng/mL)	0.59(0.28, 1.60)	0.75(0.13, 3.03)	−0.449^b	0.654
PaO2(mmHg)	76.50(64.00, 102.75)	75.50(64.50, 92.25)	−0.451^b	0.652
Base Excess	−1.10(−4.40, 0.75)	−3.70(−9.93, −0.15)	−2.194^b	0.028

Notes: ^at value; ^bZ value; ^cχ^2.

Abbreviations: New JSS, new Japan Severity Score; SBP, systolic blood pressure; DBP, diastolic blood pressure; WBC, white blood cells; APTT, activated partial thromboplastin time; HDL, high density lipoprotein; LDL, low density lipoprotein; PaO₂, arterial oxygen partial pressure.

Table 2 Results of Multivariate Analysis of SACI

	B	SE	Wald	P	OR(95% CI)
New Japan Severity Score	0.536	0.158	11.543	0.001	1.709(1.254, 2.327)
Creatine Kinase Isoenzyme	0.025	0.010	6.032	0.014	1.026(1.005, 1.046)
White Blood Cells	0.096	0.044	4.822	0.028	1.101(1.010, 1.200)
Troponin I	0.035	0.015	5.477	0.019	1.036(1.006, 1.067)
Constant Variable	−5.825	2.067	7.941	0.005	0.003

Figure 1 Effect analysis of the prediction model in this study.

Abbreviation: AUC, area under receiver operating characteristic curve.

Figure 2 Comparison between the prediction model and the new JSS prediction model.

Data Sharing Statement

Data used in this study can be requested from the corresponding author with a justification.