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Original Research

Real world outcomes of adding rapid-acting insulin versus switching to analog premix insulin among US patients with type 2 diabetes treated with insulin glargine

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Pages 951-960 | Published online: 19 Sep 2013

Figures & data

Table 1 Clinical and economic characteristics at baseline

Figure 1 Treatment persistence (A) and adherence (B) in the basal–bolus (GLA + RAI) and premix insulin (PMX) cohorts over 1-year of follow-up. In addition to the 90th percentile data, sensitivity analyses involving the 75th and 95th percentile are shown for persistence data.

Abbreviations: GLA, insulin glargine; RAI, rapid-acting insulin; PMX, premixed insulin; MPR, medication possession ratio.
Figure 1 Treatment persistence (A) and adherence (B) in the basal–bolus (GLA + RAI) and premix insulin (PMX) cohorts over 1-year of follow-up. In addition to the 90th percentile data, sensitivity analyses involving the 75th and 95th percentile are shown for persistence data.

Figure 2 Kaplan–Meier curve for the time to treatment discontinuation.

Abbreviations: GLA, insulin glargine; RAI, rapid-acting insulin; PMX, premixed insulin.
Figure 2 Kaplan–Meier curve for the time to treatment discontinuation.

Figure 3 A1C reduction among patients in the basal–bolus (GLA + RAI, n = 207) and premixed insulin (PMX, n = 234) cohorts who had baseline and follow-up data available.

Abbreviations: A1C, glycated hemoglobin; GLA, insulin glargine; RAI, rapid-acting insulin; PMX, premixed insulin.
Figure 3 A1C reduction among patients in the basal–bolus (GLA + RAI, n = 207) and premixed insulin (PMX, n = 234) cohorts who had baseline and follow-up data available.

Figure 4 Hypoglycemia prevalence (A) and incidence (B) at the end of the 1-year follow-up.

Abbreviations: GLA, insulin glargine; RAI, rapid-acting insulin; PMX, premixed insulin; ED, emergency department.
Figure 4 Hypoglycemia prevalence (A) and incidence (B) at the end of the 1-year follow-up.

Figure 5 Health care cost outcomes over 1 year of follow-up.

Abbreviations: GLA, insulin glargine; RAI, rapid-acting insulin; PMX, premixed insulin; ED, emergency department.
Figure 5 Health care cost outcomes over 1 year of follow-up.

Table 2 Health care resource utilization over 1 year of follow-up