Figures & data
Table 1 Characteristics of included trials in this meta-analysis
Table 2 Methodological quality of included trials
Figure 2 Forest plot of the mortality compared to the thrombolysis with heparin for the patients with acute submassive PE.
Abbreviations: M–H, Mantel–Haenszel test; CI, confidence interval; PAIMS 2, Plasminogen Activator Italian Multicenter Study 2; PIOPED, Prospective Investigation of Pulmonary Embolism Diagnosis.
![Figure 2 Forest plot of the mortality compared to the thrombolysis with heparin for the patients with acute submassive PE.](/cms/asset/cd78e653-7d05-4833-8636-c6adb16d3594/dppa_a_56280_f0002_c.jpg)
Figure 3 Forest plot of recurrent PE compared to the thrombolysis with heparin for the patients with acute submassive PE.
Abbreviations: M–H, Mantel–Haenszel test; CI, confidence interval; PAIMS 2, Plasminogen Activator Italian Multicenter Study 2; PIOPED, Prospective Investigation of Pulmonary Embolism Diagnosis.
![Figure 3 Forest plot of recurrent PE compared to the thrombolysis with heparin for the patients with acute submassive PE.](/cms/asset/27890519-6035-4977-81e3-96781d3253eb/dppa_a_56280_f0003_c.jpg)
Figure 4 Forest plot of major bleeding compared the thrombolysis with heparin for the patients with acute submassive PE.
Abbreviations: M–H, Mantel–Haenszel test; CI, confidence interval; PAIMS 2, Plasminogen Activator Italian Multicenter Study 2; PIOPED, Prospective Investigation of Pulmonary Embolism Diagnosis.
![Figure 4 Forest plot of major bleeding compared the thrombolysis with heparin for the patients with acute submassive PE.](/cms/asset/5304c55f-67f7-42d7-b8f6-9fef992245b9/dppa_a_56280_f0004_c.jpg)
Figure 5 Forest map of minor bleeding compared the thrombolysis with heparin for the patients of acute submassive PE.
Abbreviations: M–H, Mantel–Haenszel test; CI, confidence interval; PAIMS 2, Plasminogen Activator Italian Multicenter Study 2; PIOPED, Prospective Investigation of Pulmonary Embolism Diagnosis.
![Figure 5 Forest map of minor bleeding compared the thrombolysis with heparin for the patients of acute submassive PE.](/cms/asset/b3d537a9-a4ec-461c-89f4-369442028f38/dppa_a_56280_f0005_c.jpg)
Figure 6 Funnel plot of overall effect for mortality versus study precision.
![Figure 6 Funnel plot of overall effect for mortality versus study precision.](/cms/asset/a431896b-6dc4-4dec-b5d8-3250316edb9e/dppa_a_56280_f0006_c.jpg)