Acceptability of bone antiresorptive therapy among HIV-infected adults at different stages of antiretroviral therapy

Figures & data

Figure 1 Flowchart of participants approached and included.

Table 1 Respondent characteristics

Variable	Valuea
Sex
Male	89 (78.8)
Female	23 (21.2)
Other	0
Age	43 (36–51)
Race
Caucasian	47 (42.0)
Black	34 (30.4)
Asian	12 (10.1)
Other	17 (15.8)
ART use
ART naïve	28 (25.0)
Initiated ART within 12 months	26 (23.2)
Initiated ART >12 months	58 (51.8)
HIV risk factors
MSM	61 (54.5)
IDU	2 (1.8)
Blood product	4 (3.6)
Heterosexual	39 (34.8)
Other/unknown	6 (5.4)
Years since HIV diagnosis	8 (3–12)
Current CD4 count (cells/mm^3)	477 (297–615)
Nadir CD4 count (cells/mm^3)	207 (94–380)
Viral load undetectable (<40 copies/mL)
ART naïve	2 (7.1)
Initiated ART within 12 months	12 (46.2)
Initiated ART >12 months	54 (93.1)
Fracture history
No previous fracture	86 (78.9)
Previous facture	23 (21.1)
Previous bone mineral density test
Yes	12 (10.7)
No	100 (89.3)
Vitamin D use
Yes	28 (25.0)
No	84 (75.0)
Problems with history of heartburn, reflux, or stomach acidb
Yes	39 (35.1)
No	72 (64.9)

a Notes: Values shown are median (interquartile range) and frequency (percentage).

b One participant did not respond to this question.

Abbreviations: ART, antiretroviral therapy; IDU, injection drug user; MSM, man who has sex with men.

Table 2 Characteristics associated to willingness to take antiresorptive therapy

Variable	Univariable model		Multivariable model
	Odds ratio (95% CL)	P-value	Odds ratio (95% CL)	P-value
Male	0.07 (0.02, 0.33)	0.0006	0.05 (0.01, 0.24)	0.0003
ART status
ART naïve	1.00
Initiated ART within 12 months	1.67 (0.66, 4.22)	0.28
Initiated ART >12 months	0.84 (0.34, 2.08)	0.57
Undetectable viral load (<40 copies/mL)	0.61 (0.28, 1.33)	0.15
Number of medications/day	0.94 (0.85, 1.05)	0.26
Number of pills/daya	0.94 (0.87, 1.02)	0.12	1.12 (1.01, 1.25)	0.03
Prior fracture	1.34 (0.52, 3.49)	0.55	0.43 (0.13, 1.42)	0.17
Number of osteoporotic risk factors	0.89 (0.54, 1.47)	0.66	0.47 (0.20, 1.12)	0.09
Knows definition of osteoporosis	0.83 (0.38, 1.80)	0.63

a Note: Number of pills/day refers to all medications taken by patient.

Abbreviations: ART, antiretroviral therapy; CL, confidence limit.

Figure 2 Perceived definitions of fracture risk.

Notes: The diamond represents the mean. The circle represents an outlier.