Patients’ compliance with different administration routes for allergen immunotherapy in Germany

Figures & data

Table 1 Definition of “completed treatment years” according to the number of AIT prescriptions per patient

Completed treatment years		≥1 year	≥2 years	≥3 years
Number of prescriptions (Rx)*	Preseasonal SCIT	≥1 Rx	≥2 Rx	≥3 Rx
	Perennial SCIT	≥2 Rx	≥3 Rx	≥5 Rx
	SLIT	≥2 Rx	≥5 Rx	≥8 Rx

Note:

* Maintenance treatment sets containing two vials were counted as two units.

Abbreviations: AIT, allergen immunotherapy; SCIT, subcutaneous immunotherapy; SLIT, sublingual immunotherapy.

Table 2 Number of patients receiving prescriptions for SCIT or SLIT included in the analysis

	Total (any age)	5–11 years	12–17 years	≥18 years
SCIT with high-dose hypoallergenic preparations (allergoids)
Pollen, perennial	19,539	521	2,952	16,066
Pollen, preseasonal	44,355	749	5,030	38,576
Mites	9,952	339	1,890	7,723
SCIT with unmodified preparations
Pollen, perennial	7,758	125	922	6,711
Mites	3,637	123	640	2,874
SLIT
Pollen	706	43	93	570

Abbreviations: SCIT, subcutaneous immunotherapy; SLIT, sublingual immunotherapy.

Figure 1 Patients’ compliance with pollen (A) or mite (B) AIT.

Abbreviations: AIT, allergen immunotherapy; SCIT, subcutaneous immunotherapy; SLIT, sublingual immunotherapy.

Figure 2 Compliance with high-dose hypoallergenic pollen SCIT administered perennially or preseasonally.

Abbreviation: SCIT, subcutaneous immunotherapy.

Figure 3 Compliance with perennially applied high-dose hypoallergenic pollen SCIT, unmodified pollen SCIT and pollen SLIT.

Abbreviations: SCIT, subcutaneous immunotherapy; SLIT, sublingual immunotherapy.

Table 3 Percentage number of patients completing at least 1, 2, or 3 treatment years with the different SCIT or SLIT preparations in children 5–11 years, adolescents 12–17 years, and adults 18 years and older

Treatment scheme	At least 1 year	At least 2 years	At least 3 years
SCIT with high-dose hypoallergenic preparations
Pollen, perennial
5–11 years	100%	93%	73%
12–17 years	100%	91%	68%
≥18 years	100%	85%	58%
Pollen, preseasonal
5–11 years	100%	61%	44%
12–17 years	100%	57%	36%
≥18 years	100%	47%	26%
Mites
5–11 years	83%	77%	65%
12–17 years	81%	76%	64%
≥18 years	72%	67%	51%
SCIT with unmodified preparations
Pollen, perennial
5–11 years	77%	72%	57%
12–17 years	73%	67%	49%
≥18 years	64%	58%	41%
Mites
5–11 years	80%	77%	57%
12–17 years	74%	71%	58%
≥18 years	62%	59%	42%
SLIT
Pollen
5–11 years	61%	33%	23%
12–17 years	54%	30%	17%
≥18 years	52%	25%	15%

Abbreviations: SCIT, subcutaneous immunotherapy; SLIT, sublingual immunotherapy.