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Original Research

Systematic review and meta-analysis of prospective studies for ECP treatment in patients with steroid-refractory acute GVHD

, , , &
Pages 105-111 | Published online: 17 Jan 2015

Figures & data

Figure 1 Identification and selection of studies for steroid-refractory acute graft-versus-host disease.

Abbreviations: aGVHD, acute graft-versus-host disease; ECP, extracorporeal photopheresis; GVHD, graft-versus-host disease; SR-aGVHD, steroid-refractory acute graft-versus-host disease.
Figure 1 Identification and selection of studies for steroid-refractory acute graft-versus-host disease.

Table 1 Characteristics of the included studies

Table 2 Quality of included studies

Figure 2 Overall response rate of ECP in the treatment of SR-aGVHD.

Note: Weights are from random-effects analyses.
Abbreviations: CI, confidence interval; ECP, extracorporeal photopheresis; ES, effect size; SR-aGVHD, steroid-refractory acute graft-versus-host disease.
Figure 2 Overall response rate of ECP in the treatment of SR-aGVHD.

Figure 3 Complete response rate of ECP in the treatment of SR-aGVHD.

Note: Weights are from random-effects analyses.
Abbreviations: CI, confidence interval; ECP, extracorporeal photopheresis; ES, effect size; SR-aGVHD, steroid-refractory acute graft-versus-host disease.
Figure 3 Complete response rate of ECP in the treatment of SR-aGVHD.

Figure 4 (A) Efficacy of ECP for skin SR-aGVHD, (B) funnel plot with pseudo 95% confidence limits.

Note: Weights are from random-effects analyses.
Abbreviations: CI, confidence interval; ECP, extracorporeal photopheresis; ES, effect size; SE, standard error; SR-aGVHD, steroid-refractory acute graft-versus-host disease.
Figure 4 (A) Efficacy of ECP for skin SR-aGVHD, (B) funnel plot with pseudo 95% confidence limits.

Figure 5 (A) Efficacy of ECP for liver SR-aGVHD, (B) funnel plot with pseudo 95% confidence limits.

Note: Weights are from random-effects analyses.
Abbreviations: CI, confidence interval; ECP, extracorporeal photopheresis; ES, effect size; SE, standard error; SR-aGVHD, steroid-refractory acute graft-versus-host disease.
Figure 5 (A) Efficacy of ECP for liver SR-aGVHD, (B) funnel plot with pseudo 95% confidence limits.

Figure 6 (A) Efficacy of ECP for gut SR-aGVHD, (B) funnel plot with pseudo 95% confidence limits.

Note: Weights are from random-effects analyses.
Abbreviations: CI, confidence interval; ECP, extracorporeal photopheresis; ES, effect size; SE, standard error; SR-aGVHD, steroid-refractory acute graft-versus-host disease.
Figure 6 (A) Efficacy of ECP for gut SR-aGVHD, (B) funnel plot with pseudo 95% confidence limits.