Figures & data
Figure 1 Clinically significant weight loss with bupropion and bupropion naltrexone combination in 6 months.
Notes: Lower numbers more effective; most effective medications have NNTs between 2 and 4. Statistical term NNT denotes number of patients needed to be treated to get one desired clinical outcome compared to placebo. Summary results of all studies:Citation10,Citation15,Citation16,Citation18 N=845; Bup =463; Bup + Ntx 16 mg =54; Bup + Ntx 32 mg =888; Bup + Ntx 48 mg =54. Study durations ranged between 24 and 26 weeks. Bupropion doses ranged between 300 and 400 mg. Naltrexone 48 mg alone performed worse than placebo; thus, NNT was negative (not shown in graph). All groups, including placebo, received lifestyle interventions and calorie-reducing diet in all studies.
Abbreviations: TBW, total body weight; NNT, number needed to treat; N, placebo; Bup, bupropion; Ntx, naltrexone.
Abbreviations: TBW, total body weight; NNT, number needed to treat; N, placebo; Bup, bupropion; Ntx, naltrexone.
Figure 2 Clinically significant weight loss with bupropion and bupropion naltrexone combination in 1 year.
Notes: Lower numbers more effective; most effective medications have NNTs between 2 and 4. Statistical term NNT denotes number of patients needed to be treated to get one desired clinical outcome compared to placebo. Summary results of all studies:Citation10,Citation18–Citation21 N=1,319; Bup =57; Bup + Ntx 16 mg =525; Bup + Ntx 32 mg =2,106; Bup + Ntx 48 mg =54. Study durations ranged between 48 and 56 weeks. Bupropion doses ranged between 360 and 400 mg. Bupropion alone performed worse than placebo for 10% or more TBW loss; thus, NNT was negative (not shown in graph). All groups, including placebo, received lifestyle interventions and calorie-reducing diet in all studies.
Abbreviations: TBW, total body weight; NNT, number needed to treat; N, placebo; Bup, bupropion; Ntx, naltrexone.
Abbreviations: TBW, total body weight; NNT, number needed to treat; N, placebo; Bup, bupropion; Ntx, naltrexone.
