Patient-reported treatment satisfaction and choice of dosing frequency with biologic treatment for moderate to severe plaque psoriasis

Figures & data

Figure 1 Sample selection and attrition.

Notes: The overall response rate was 24.8% of all invited patients, with 21.3% eligible for inclusion with complete surveys. By cohort, 23.9% of biologic-experienced patients sent invitations provided complete responses, and 18.0% of biologic-naïve patients provided complete responses.

Table 1 Demographic and clinical characteristics of study population

	Biologic-naïve (n=163)	Biologic-experienced (n=263)	P-value
Age, years, mean (SE)	51 (0.8)	49 (0.7)	0.009**
Sex, % male	55	58	0.461
BMI, mean (SE)	29 (0.5)	30 (0.4)	0.156
Race, %
Asian	2	3	0.904
American Indian or Native Alaskan	2	2	0.789
Black or African American	4	1	0.014***
White	89	91	0.631
General health status, %
Excellent	11	17	0.065
Very good	35	33	0.683
Good	39	35	0.322
Fair	12	13	0.693
Poor	3	2	0.434
Psoriasis severity, %
Very mild	10	8	0.407
Mild	17	13	0.278
Moderate	45	37	0.076
Severe	23	36	0.004**
Extremely severe	6	7	0.589
Handprint-sized areas with lesions, mean (SD)	5 (0.44)	8 (0.72)	0.002**
Most common location of psoriasis lesions, %
Elbow	67	73
Scalp	72	72
Shin	51	64
Years since diagnosis	14 (0.95)	19 (0.79)	<0.001*

Notes:

* P<0.001;

** P<0.01;

*** P<0.05.

Abbreviations: BMI, body mass index; SD, standard deviation; SE, standard error.

Figure 2 Satisfaction with current psoriasis medication over the last 2–3 weeks or since last use.

Notes: Mean scores for each domain of questions regarding satisfaction. Scales are based upon the Treatment Satisfaction Questionnaire for Medication and have a range of 1–100. *P<0.001.

Figure 3 Choice of dosing frequency. Comparison within cohorts, percentages preferring once every 2–3 months vs once every 1–2 weeks (^†P<0.001, ^‡P=0.264). Comparison between cohorts, percentages preferring once every 2–3 months (*P=0.004).

Figure 4 Specific dose interval selection.

Notes: Percentages of patients who chose each dose interval option when asked “If your physician provided you with several options for the frequency of an injection maintenance medication for your psoriasis, which of the following would you request?” Possible choices were whole week intervals (1 through 12) between doses.