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Original Research

Reduction of exercise capacity in sarcoidosis in relation to disease severity

, , , , , , , , , , , & show all
Pages 1179-1188 | Published online: 18 Aug 2015

Figures & data

Table 1 Clinical characteristics and pulmonary function tests in 83 patients with sarcoidosis classified according to radiological stage of the disease

Table 2 Cardiopulmonary exercise test results in 83 patients with sarcoidosis classified according to radiological stage of the disease

Figure 1 VO2 peak correlations with clinical, functional, and cardiopulmonary test parameters in 83 patients with sarcoidosis.

Note: P<0.001 for all comparisons.
Abbreviations: FVC%, percent forced vital capacity; %pred, percent predicted; AT, anaerobic threshold; DLCO, diffusing capacity of the lung for carbon monoxide; VE, minute ventilation; VO2 peak, peak oxygen consumption; VT, tidal volume.
Figure 1 VO2 peak correlations with clinical, functional, and cardiopulmonary test parameters in 83 patients with sarcoidosis.

Table 3 Correlation of functional variables at rest with peak oxygen consumption (VO2 peak) in 83 patients with sarcoidosis according to radiological stages

Figure 2 Biplot of correlation coefficients (loading factors) of ergo/spirometric variables with PCA axes 1 and 2. The longer the arrow the greater effect is produced by the variable. Variables forming oblique angles correlate positively with each other and negatively at arrows with obtuse angles. The lower oblique or wider obtuse aperture the higher the correlation coefficient.

Abbreviations: AT, anaerobic threshold; DLCO, diffusing capacity of the lung for carbon monoxide; FEF25–75, forced expiratory flow 25%–75%; FEV1, forced expiratory volume in 1 second; FVC, forced vital capacity; FVC%, percent forced vital capacity; HR, heart rate; PCA, principal component analysis; RV%, percent residual volume; TLC, total lung capacity; VCO2, carbon dioxide production; VE, minute ventilation; VO2, oxygen consumption; VT, tidal volume; vom%, maximal aerobic capacity.
Figure 2 Biplot of correlation coefficients (loading factors) of ergo/spirometric variables with PCA axes 1 and 2. The longer the arrow the greater effect is produced by the variable. Variables forming oblique angles correlate positively with each other and negatively at arrows with obtuse angles. The lower oblique or wider obtuse aperture the higher the correlation coefficient.

Figure 3 PCA scores and patients position as arranged by the two major axes according to radiological Stages I–III and the combined presence/absence of ecto-pneumonic location and restriction rules.

Abbreviation: PCA, principal component analysis.
Figure 3 PCA scores and patients position as arranged by the two major axes according to radiological Stages I–III and the combined presence/absence of ecto-pneumonic location and restriction rules.

Figure 4 Mean changes of the significant ergo-/spirometric variables with the radiological conditions 1–3.

Abbreviations: DLCO%, percent diffusing capacity of the lung for carbon monoxide; FEV1%, percent forced expiratory volume in 1 second; FEF25–75, forced expiratory flow 25%–75%; FVC%, percent forced vital capacity; TLC, total lung capacity; VCO2, carbon dioxide production; VO2, oxygen consumption; VO2 max, maximum oxygen consumption; vom%, maximal aerobic capacity; VD, deadspace; VE, minute ventilation; VT, tidal volume; vom%, maximal aerobic capacity; HR, heart rate.
Figure 4 Mean changes of the significant ergo-/spirometric variables with the radiological conditions 1–3.

Figure 5 Mean changes of VO2 peak along with the ordinal categories of diffusing capacity of the lung for carbon monoxide (DLCO).

Notes: Vertical lines indicate the 95% confidence intervals of means calculated from the error mean square of analysis of variance. Means whose intervals do not overlap differ significantly.
Figure 5 Mean changes of VO2 peak along with the ordinal categories of diffusing capacity of the lung for carbon monoxide (DLCO).

Table 4 Correlation of cardiopulmonary test variables with VO2 peak in 83 patients with sarcoidosis according to radiological stages