Factors related to changes in the quality of life among Polish adolescents and adults with cystic fibrosis over a 1-year period

Figures & data

Table 1 Spirometric indices and Shwachman–Kulczycki’s (Sh–K) scale values at the first and the second examination (n=67)

Variable	Baseline	After 1 year	P-value
Spirometry
FEV1 (% predicted)	47.8±22.3	40.2±19.6	<0.001
FVC (% predicted)	63.3±23.3	57.4±20.5	0.026
FEV1/FVC ratio	66.2±13.9	61.0±14.0	<0.001
MMEF (% predicted)	35.8±25.7	23.1±23.1	<0.001
Sh–K scale (points)
General activity level	17.4±6.5	15.8±6.6	<0.001
Physical examination	14.7±4.9	14.0±5.1	0.014
Physical development and nutrition	20.5±4.2	19.6±4.9	0.002
X-ray findings	13.5±3.9	12.7±4.2	0.002
Total Sh–K score	64.2±18.6	60.7±20.3	0.041
Body mass index	18.0±2.8	17.7±2.8	0.562
RSCL – physical activity	86.0±19.9	89.5±31.2	0.256

Note: Values presented as arithmetic means ± standard deviations.

Abbreviations: FEV₁, forced expiratory volume in 1 second; FVC, forced vital capacity; RSCL, Rotterdam Symptom Checklist; MMEF, maximum midexpiratory flow.

Table 2 Quality of life scores across all domains at the first and second examinations (n=67)

Variable	Baseline	After 1 year	P-value	Subjects with HRQoL improvement (%)	Subjects with the same HRQoL (%)	Subjects with HRQoL deterioration (%)
Physical functioning	73.1±22.1	69.1±25.3	0.081	32.8	6.0	61.2
Social functioning	72.5±25.4	75.0±35.6	0.550	49.3	13.4	37.3
Treatment issues	66.2±26.4	63.8±26.9	0.501	44.8	17.9	37.3
Chest symptoms	63.1±26.9	60.5±25.6	0.411	32.8	13.4	53.8
Emotional functioning	68.1±22.3	65.7±25.7	0.379	38.8	6.0	55.2
Future concerns	50.3±20.5	48.0±24.0	0.262	40.3	11.9	47.7
Relationships	57.0±22.0	54.7±23.8	0.265	44.8	3.0	52.2
Body image	54.9±26.9	53.0±28.5	0.270	37.3	17.2	44.8
Career concerns	56.9±23.3	52.0±24.4	0.063	35.8	13.4	50.8
Total quality of life score	63.1±16.9	60.3±18.0	0.114	40.3	1.5	58.2

Note: Values presented as arithmetic mean ± standard deviation.

Abbreviation: HRQoL, health-related quality of life.

Table 3 Sensitive quality of life (QoL) domains and list of possible interventions

QoL domain	Positive influence	Possible interventions
Treatment issues	• FEV1 >50% predicted	• Optimal treatment
Career concerns	• FVC >50% predicted	• Optimal treatment
	• Perception of physical condition	• Regular exercise
Social functioning	• Short period from last exacerbation	• Periodical (preventive) therapy?
Future concerns	• Ability to perform daily activities	• Optimal treatment
	• Living conditions	• Social support
	• Residing in cities

Abbreviations: FEV₁, forced expiratory volume in the 1 second; FVC, forced vital capacity.