Magnetic resonance enterography or video capsule endoscopy – what do Crohn’s disease patients prefer?

Figures & data

Table 1 Demographic data and disease characteristics

Sex, n
Female	23
Male	33
Age (years), mean ± SD	32±11
Disease duration (years), mean ± SD	6±5
Disease location, n
Small bowel disease	53
Small bowel + colonic disease	31
Upper GI	2
Perianal disease	8
Previous CD-related surgery, n	10
Clinical remission (CDAI <150), n	49
Current medications, n
Systemic corticosteroids	1
Thiopurines	26
5-ASA	8
Anti-TNF	24

Abbreviations: GI, gastrointestinal; CD, Crohn’s disease; CDAI, Crohn’s disease activity index; 5-ASA, aminosalicylate; TNF, tumor necrosis factor.

Figure 1 Main procedures’ tolerability parameters.

Notes: (A) Pre-exam discomfort, P<0.0001. (B) Discomfort during the exam, P<0.0001. (C) Difficulty, P<0.0001.
Abbreviation: MRE, magnetic resonance enterography.

Table 2 Tolerability to MRE versus CE

Subject	MRE (severity degree ± SD), N=56	CE (severity degree ± SD), N=56	P-value
Home preparation	2.38±1.32	2.68±1.13	0.1215
Pre-exam discomfort	2.7±1.22	1.5±0.99	<0.0001
Discomfort during the exam	3.7±1.22	2.0±1.08	<0.0001
Nausea	2.22±1.18	1.29±0.53	<0.0001
Vomiting	1.5±1.05	1.07±0.37	0.009
Bloating	2.01±1.14	1.25±0.55	0.0002
Abdominal pain	2.24±1.1	1.33±0.63	<0.0001
Tenesmus	1.40±0.87	1.14±0.55	0.0389
Claustrophobia	1.40±0.7	1±0	<0.0001
Time consuming	3.46±1.19	3.0±1.23	0.0594
Difficulty	3.42±1.13	2.03±0.98	<0.0001
Drinking of contrast material	3.2±1.22	NR	NR

Notes: Score: 1= none to 5= severe. P-value: Mann–Whitney U test. P<0.05 was considered significant.

Abbreviations: MRE, magnetic resonance enterography; CE, capsule endoscopy; NR, not relevant; SD, standard deviation.

Table 3 Tolerability to MRE versus colonic CE

Subject	MRE (severity degree ± SD), N=7	Colon CE (severity degree ± SD), N=7	P-value
Home preparation	2.0±1.41	3.57±1.49	0.0916
Pre-exam discomfort	3.14±1.12	3.57±1.29	0.4319
Discomfort during the exam	3.28±1.03	2.28±1.48	0.1571
Nausea	2.14±1.12	2.14±0.63	0.8963
Vomiting	1.57±1.05	1.57±0.9	1.0000
Bloating	2.42±0.9	1.42±0.49	0.0474
Abdominal pain	2.0±0.53	1.42±0.49	0.0973
Tenesmus	1.71±1.16	1.2±0.69	0.5220
Claustrophobia	1.00±0	1±0	1.0000
Time consuming	3.57±1.04	4.0±0.75	0.434
Difficulty	3.57±1.17	3.0±1.41	0.4793
Drinking of contrast material	3.7±0.88	NR	NR

Notes: Score: 1= none to 5= severe. P-value: Mann–Whitney U test. P<0.05 was considered significant.

Abbreviations: MRE, magnetic resonance enterography; CE, capsule endoscopy; NR, not relevant; SD, standard deviation.

Table 4 Tolerability to MRE versus SBCE

Parameter	MRE (severity degree ± SD), N=49	SBCE (severity degree ± SD), N=49	P-value
Home preparation	2.41±1.30	2.52±1.02	0.4086
Pre-exam discomfort	2.60±1.23	1.22±0.46	<0.0001
Discomfort during the exam	3.70±1.22	1.93±1.00	<0.0001
Nausea	2.23±1.19	1.66±0.37	<0.0001
Vomiting	1.48±1.04	1.00±0.00	0.0028
Bloating	1.93±1.16	1.23±0.55	0.0009
Abdominal pain	2.27±1.14	1.31±0.65	<0.0001
Tenesmus	1.39±0.83	1.16±0.59	0.0648
Claustrophobia	1.45±0.73	1±0	<0.0001
Time consuming	3.42±1.12	2.85±1.20	0.0312
Difficulty	3.42±1.11	1.87±0.80	<0.0001
Drinking of contrast material	3.42±1.23	NR	NR

Notes: Score: 1= none to 5= severe. P-value: Mann–Whitney U test. P<0.05 was considered significant.

Abbreviations: MRE, magnetic resonance enterography; SBCE, small bowel capsule endoscopy; NR, not relevant; SD, standard deviation.

Table 5 Tolerability to colonic CE versus SBCE

Subject	SBCE (severity degree ± SD), N=49	Colon CE (severity degree ± SD), N=7	P-value
Home preparation	2.52±1.02	3.57±1.49	0.0721
Pre-exam discomfort	1.22±0.46	3.57±1.29	<0.0001
Discomfort during the exam	1.93±1.00	2.28±1.48	0.7896
Nausea	1.66±0.37	2.14±0.63	0.0001
Vomiting	1.00±0.00	1.57±0.9	0.0021
Bloating	1.23±0.55	1.42±0.49	0.1666
Abdominal pain	1.31±0.65	1.42±0.49	0.3482
Tenesmus	1.16±0.59	1.2±0.69	0.6408
Claustrophobia	1±0	1±0	1.0000
Time consuming	2.85±1.20	4.0±0.75	0.0189
Difficulty	1.87±0.80	3.0±1.41	0.0395

Notes: Score: 1= none to 5= severe. P-value: Mann–Whitney U test. P<0.05 was considered significant.

Abbreviations: CE, capsule endoscopy; SBCE, small bowel capsule endoscopy; SD, standard deviation.

Figure S1 Questionnaire – post CE.

Abbreviations: CE, capsule endoscopy; MRE, magnetic resonance enterography.