DNA methyltransferase 3A gene polymorphism contributes to daily life stress susceptibility

Figures & data

Figure 1 Visualization of the DNMT3A rs11683424 polymorphism using agarose gel electrophoresis.

Figure 2 Frequency and variants of the DNMT3A gene (CC, CT, and TT) in healthy subjects.

Table 1 Hardy–Weinberg equilibrium for the observed and expected genotype frequencies for DNMT3A rs11683424

Genotype	Observed	Expected	p-value
CC	18 (13.95%)	38.53 (29.87%)	0.00
CT	105 (81.4%)	63.94 (49.57%)
TT	6 (4.65%)	26.53 (20.57%)

Table 2 The Kessler Psychological Distress Scale (K10) of healthy subjects: distribution correlated with the variations of genotype

Genotype	Stress level
	No	Mild	Moderate	Severe
CC	2	8	3	5
CT	29	38	29	9
TT	2	2	1	1
n	33	48	33	15
Percentage	25.58	37.21	25.58	11.63

Figure 3 The Kessler Psychological Distress Scale (K10) of healthy subjects: distribution correlated with the variation of genotype (bar graphs).

Table 3 The rs11683424 variant of DNMT3A and gender

Stress	Women (n)			Men (n)
	CC	CT	TT	CC	CT	TT
No	2	21	2	0	8	0
Mild	5	29	1	3	9	1
Moderate	2	21	2	1	7	0
Severe	4	6	0	1	3	1
Total (n)	13	77	5	5	27	2