Quality of Life and Depression in Rheumatoid Arthritis Patients Treated with Biologics – A Single Centre Experience

Figures & data

Table 1 Socio-Clinical Characteristics of the Study Group

Parameter		Total
Age [years]	Mean±SD	52.38±16.97
	Median	55
	Quartiles	39.5–64
Disease duration [years]	Mean±SD	13.54±9.51
	Median	10
	Quartiles	7–19
Relationship status	In a relationship	63.37%
	Single	36.63%
DAS-28	Mean±SD	4.8±0.8
Gender	Female	62.90%
	Male	37.10%
BMI	Normal weight	58.12%
	Overweight	27.59%
	Obesity	14.29%
Comorbidities	Hypertension	20.79%
	Diabetes	7.92%
	Atherosclerosis	4.95%
	Asthma	5.94%
	Osteoporosis	0.99%
	Hypothyroidism	17.82%
	Sjogren’s syndrome	2.97%
	Psoriasis	20.79%
	None	38.61%
Biologics treatment	Certolizumab	6.93%
	Etanercept	14.85%
	Adalimumab	2.97%
	Golimumab	1.98%
	Baricitinib	5.94%
	Tocilizumab	67.33%
VAS	Mean±SD	4.4±2.7
HADS: anxiety	Mean±SD	20.0±2.3
	Normal	65.08%
	Borderline	28.57%
	Abnormal	6.35%
HADS: depression	Mean±SD	17.1±2.2
	Normal	71.42%
	Borderline	14.29%
	Abnormal	14.29%
WHOQOL-BREF	Perception of health	2.63±1.0
	Perception of quality of life	3.48 ± 0.8
	Physical health domain	11.0±2.44
	Psychological domain	17.0±2.12
	Social relationships domain	15.5±2.09
	Environment domain	14.0±2.17

Abbreviations: SD, standard deviation; WHOQOL-BREF, The World Health Organization Quality of Life Questionnaire; VAS, Visual Analogue Scale; HADS, Hospital Anxiety and Depression Scale; DAS 28, Disease Activity Score.

Table 2 Perception of QoL and Health in the Patients Studied

Perception	Perception of Quality of Life		Perception of Health
	n	%	n	%
Very poor	2	1.98%	10	9.90%
Poor	8	7.92%	43	42.57%
Neither poor nor good	38	37.62%	25	24.76%
Good	46	45.55%	19	18.81%
Very good	7	6.93%	4	3.96%

Table 3 Results of the Analysis of Correlations Between Anxiety, Depression (HADS) and QoL (WHOQOL-BREF) in RA Patients

WHOQOL-BREF	Anxiety	Depression
	Spearman Correlation Coefficient
Perception of quality of life	r=−0.029, p=0.821	r=−0.168, p=0.187
Perception of health	r=−0.033, p=0.796	r=−0.221, p=0.051*
Physical health domain	r=−0.097, p=0.448	r=−0.209, p=0.04*
Psychological domain	r=−0.472, p<0.001	r=−0.322, p=0.01*
Social relationships domain	r=−0.298, p=0.023	r=−0.198, p=0.124
Environment domain	r=−0.055, p=0.618	r=−0.104, p=0.42

Note: *Statistically significant relationship (p<0.05).

Abbreviation: WHOQOL-BREF, The World Health Organization Quality of Life Questionnaire.