Validity and reliability of the Patient-Reported Arthralgia Inventory: validation of a newly-developed survey instrument to measure arthralgia

Figures & data

Figure 1 Flow diagram of cohort screening and enrollment.

Abbreviations: AI, aromatase inhibitor; ECOG, Eastern Cooperative Oncology Group.

Figure 2 Test-retest reliability. Bland-Altman plot of agreement between Patient-Reported Arthralgia Inventory assessments taken 2 weeks apart, with smoothed curve.

Table 1 Estimated ICC and Spearman ρ for PRAI scores for one patient taken 2 weeks apart

Weeks	Test	Test statistic	95% CI	P-value
0, 2	ICC	0.87	0.82–0.90	<0.0001
2, 4		0.94	0.92–0.96	<0.0001
4, 6		0.94	0.91–0.95	<0.0001
6, 8		0.96	0.94–0.97	<0.0001
0, 2	Spearman ρ	0.71	0.59–0.80	<0.0001
2, 4		0.86	0.78–0.91	<0.0001
4, 6		0.85	0.77–0.91	<0.0001
6, 8		0.84	0.76–0.90	<0.0001

Abbreviations: CI, confidence interval ; PRAI, Patient-Reported Arthralgia Inventory; ICC, intraclass coefficient.

Figure 3 Baseline mean Patient-Reported Arthralgia Inventory scores by presence of joint comorbidity.

Figure 4 Mean PRAI score by response to the FACT-ES item “I have pain in my joints” over time.

Abbreviations: PRAI, Patient-Reported Arthralgia Inventory; FACT-ES, Functional Assessment of Cancer Therapy-Endocrine Subscale.

Table 2 Estimated Spearman correlation between mean PRAI score and FACT-ES item “I have pain in my joints” by week

Weeks	Spearman	95% CI	P-value
0	0.82	0.78–0.87	<0.0001
2	0.80	0.74–0.85	<0.0001
4	0.76	0.69–0.83	<0.0001
6	0.80	0.75–0.85	<0.0001
8	0.82	0.77–0.87	<0.0001
12	0.82	0.76–0.86	<0.0001
16	0.81	0.73–0.87	<0.0001
52	0.79	0.72–0.85	<0.0001

Abbreviations: CI, confidence interval; FACT-ES, Functional Assessment of Cancer Therapy-Endocrine Subscale; PRAI, Patient-Reported Arthralgia Inventory.

Figure 5 Duration of morning stiffness in minutes and PRAI.

Abbreviation: PRAI, Patient-Reported Arthralgia Inventory.

Table S1 Patient-Reported Arthralgia Inventory

These questions are about pain in specific joints over the past 7 days. Please rate your pain in each joint using a number from 0 through 10, with 0 being no pain at all and 10 being the worst pain you can imagine
	0 None										10 As bad as you can imagine
Left finger joints?	0	1	2	3	4	5	6	7	8	9	10
Right finger joints?	0	1	2	3	4	5	6	7	8	9	10
Left wrist joints?	0	1	2	3	4	5	6	7	8	9	10
Right wrist joints?	0	1	2	3	4	5	6	7	8	9	10
Left elbow joint?	0	1	2	3	4	5	6	7	8	9	10
Right elbow joint?	0	1	2	3	4	5	6	7	8	9	10
Left shoulder joint?	0	1	2	3	4	5	6	7	8	9	10
Right shoulder joint?	0	1	2	3	4	5	6	7	8	9	10
Left hip joint?	0	1	2	3	4	5	6	7	8	9	10
Right hip joint?	0	1	2	3	4	5	6	7	8	9	10
Left knee joint?	0	1	2	3	4	5	6	7	8	9	10
Right knee joint?	0	1	2	3	4	5	6	7	8	9	10
Left ankle joints?	0	1	2	3	4	5	6	7	8	9	10
Right ankle joints?	0	1	2	3	4	5	6	7	8	9	10
Left toe joints?	0	1	2	3	4	5	6	7	8	9	10
Right toe joints?	0	1	2	3	4	5	6	7	8	9	10

Notes: Patient-Reported Arthralgia Inventory v2.0 ©Vanderbilt University. Dove Press and the authors request that persons interested in administering the PRAI in patient populations for research or clinical purposes write to the authors at [e-mail] asking permission to use the PRAI for your study or clinical care. Please include the following as briefly as possible: your scientific aims; your sample and recruitment methods; a list of your key collaborators; and your analysis plan. There is no charge to use the PRAI, but written permission must be granted via email, based on the authors’ review of your plans for use of this copyrighted instrument.

Abbreviation: PRAI, Patient-Reported Arthralgia Inventory.