Effect of Time (Season, Surgical Starting Time, Waiting Time) on Patients with Gastric Cancer

Figures & data

Figure 1 Inclusion and exclusion criteria of patients with gastric cancer.

Table 1 Clinical Characteristics of the Patients

Characteristics	No. 586
Sex
Male/Female	418 (71.3%)/168 (28.7%)
Age, year (mean, SD)	60.7 (± 10.7)
BMI, kg/m^2 (mean, SD)	23.2 (± 27.9)
Season of gastrectomy
Spring/Summer/Autumn/Winter	158 (27.0%)/157 (26.8%)/150 (25.6%)/121 (20.6%)
Comorbidity	216 (36.9%)
Preoperative waiting time, day (median, range)	10 (1–97)
Surgical starting time
Midday/Non-midday	132 (22.5%)/454 (77.5%)
Clinical stage I/II/III	148 (25.3%)/196 (33.4%)/242 (41.3%)
Surgical procedure
Distal gastrectomy/Total gastrectomy	409 (69.8%)/177 (30.2%)
Reconstruction methods B-I/B-II/R-Y	279 (47.6%)/116 (19.8%)/191 (32.6%)
Retrieved lymph nodes (median, range)	21 (3–70)
Operation time, minutes (median, range)	210.0 (70.0–895.0)
Estimated blood loss, mL (median, range)	100.0 (5.0–7000.0)
Postoperative hospital stay, day (median, range)	11 (3–159)
Pathological stage I/II/III/IV	137 (23.4%)/97 (16.6%)/345 (58.9%)/7 (1.1%)

Note: Variables are expressed as the mean ± SD, median or n (%).

Abbreviations: BMI, body mass index; B-I, Billroth I reconstruction; B-II, Billroth II reconstruction; R-Y, Roux-en-Y reconstruction.

Table 2 Outcomes of Midday and Non-Midday Groups

Variable	Midday Group (132)	Non-Midday Group (454)	P value
Retrieved lymph nodes (median, range)	21 (7–47)	20 (3–70)	0.132
Operation time, minutes (median, range)	202.5 (70.0–478.0)	215.0 (90.0–895.0)	0.017*
Estimated blood loss, mL (median, range)	100.0 (20.0–1000.0)	100.0 (5.0–7000.0)	0.826
Postoperative hospital stay, day (median, range)	11 (5–66)	11 (3–159)	0.424
Complications	47	120	0.048*

Note: Variables are expressed as the median, *P-value <0.05.

Table 3 Outcomes of Different Season

Variable	Spring (158)	Summer (150)	Autumn (157)	Winter (121)	P value
Retrieved lymph nodes (median, range)	20 (5–54)	21 (6–49)	21 (3–51)	19 (3–70)	0.765
Operation time, minutes (median, range)	205.0 (90.0–422.0)	217.5 (95.0–599.0)	210.0 (70.0–895.0)	225.0 (95.0–385.0)	0.385
Estimated blood loss, mL (median, range)	100 (5–2000)	100 (20–7000)	100 (10–4000)	100 (10–2500)	0.605
Postoperative hospital stay, day (median, range)	10 (3–114)	11 (4–66)	11 (5–62)	11 (5–159)	0.334
Complications	41	47	48	31	0.406

Note: Variables are expressed as the median.

Table 4 Outcomes of Short and Long Preoperative Waiting Time Groups

Variable	Short-Waiting Group (323)	Long-Waiting Group (263)	P value
Retrieved lymph nodes (median, range)	20 (5–49)	21 (3–70)	0.273
Operation time, minutes (median, range)	210.0 (70.0–895.0)	215.0 (90.0–422.0)	0.594
Estimated blood loss, mL (median, range)	100.0 (10.0–4000.0)	100.0 (5.0–7000.0)	0.114
Postoperative hospital stay, day (median, range)	11 (3–114)	10 (4–159)	0.026*
Complications	102	65	0.080

Note: Variables are expressed as the median, *P-value <0.05.

Table 5 Multivariate Analyses for the Identification of Independent Prognostic Factors for Overall Survival in All Clinical Stage Gastric Cancer

Variables	Multivariate Analyses
	HR	95%Cl	p
Sex (male/female)	1.003	0.690–1.459	0.987
Age (year)	1.017	1.001–1.033	0.040*
BMI (kg/m^2)	0.879	0.844–0.953	<0.001**
Surgical starting time	1.355	0.888–2.069	0.159
Season of gastrectomy	0.969	0.835–1.126	0.684
Comorbidity	1.049	0.741–1.484	0.788
Preoperative waiting time (day)	1.004	0.990–1.019	0.570
Clinical stage (I/II/III)	2.053	1.619–2.603	<0.001**

Notes: *P-value <0.05, **P-value <0.01.

Abbreviations: BMI, body mass index; HR, hazard ratio; CI, confidence interval.

Figure 2 Overall survival curves for patients undergoing gastrectomy. (A) Overall survival curves for the waiting groups among all patients. (B) Overall survival curves for the waiting groups among clinical stage I patients. (C) Overall survival curves for the waiting groups among clinical stage II patients. (D) Overall survival curves for the waiting groups among clinical stage III patients.

Note: The red line is the short-waiting group, and the blue line is the long-waiting group.