Evaluation of the Therapeutic Pattern and Pharmaco-Utilization in Hypercholesterolemic Patients Treated with Statins: A Retrospective Study on Italian Real-World Data

Figures & data

Table 1 Baseline Characteristics of FH, nFH Patients and nFH-Derived Cohorts

	nFH	CVD	Diabetes Mellitus	Mixed-Dyslipidemia	Primary-Prevention	P value	FH
N	164,161	46,782	34,803	1617	80,959		1287
Age (mean, SD)	72.0 (10.9)	74.3 (10.6)	71.6 (10.4)	71.4 (11.2)	70.8 (11.1)	<0.001	64.4 (12.3)
Male (n, %)	83,426 (50.8)	30,819 (65.9)	17,593 (50.6)	782 (48.4)	34,232 (42.3)	<0.001	547 (42.5%)
Charlson index (mean, SD)	1.0 (0.9)	1.2 (1.1)	1.6 (0.7)	0.6 (0.8)	0.5 (0.7)	<0.001	0.9 (1.0)
LDL-C index-value (mg/dl, mean, SD)	94.6 (34.5)	80.0 (31.4)	85.2 (30.8)	104.3 (34.5)	106.9 (33.2)	<0.001	123.4 (62.0)
≤70mg/dl (n, %)	40,227 (24.5)	19,280 (41.2)	11,432 (32.8)	228 (14.1)	9287 (11.5)	<0.001	141 (11.0%)
71–100 mg/dl (n, %)	59,117 (36.0)	17,365 (37.1)	14,190 (40.8)	589 (36.4)	26,973 (33.3)	<0.001	363 (28.2%)
101–130 mg/dl (n, %)	42,310 (25.8)	7186 (15.4)	6539 (18.8)	488 (30.2)	28,097 (34.7)	<0.001	383 (29.8%)
>130 mg/dl (n, %)	22,507 (13.7)	2951 (6.3)	2642 (7.6)	312 (19.3)	16,602 (20.5)	<0.001	400 (31.1%)

Notes: P values are referred to the comparison among nFH-derived sub-cohorts.

Abbreviations: CVD, cardiovascular disease cohort; FH, familial hypercholesterolemia; LDL-C, low-density lipoprotein cholesterol; N, number; nFH, non-familial hypercholesterolemia; SD, standard deviation.

Figure 1 Treatment patterns among nFH patients and FH patients, and their adherence to statins. At the index-date, the identification of therapeutic options prescribed among nFH (A) and FH (B) patients was assessed. The percentage of patients adherent to statin medication was evaluated during the pharmaco-utilization period (C).

Abbreviations: Atorva, atorvastatin; Simva, simvastatin; Rosuva, rosuvastatin; Lova, lovastatin; Prava, pravastatin; Fluva, fluvastatin; Ass Eze, statin associated with ezetimibe or ezetimibe alone; nFH, non-familial hypercholesterolemia; CVD, cardiovascular disease cohort; FH, familial hypercholesterolemia.