Characterization and evaluation of the directly observed treatment for tuberculosis in Santiago de Compostela (1996–2006)

Figures & data

Table 1 Distribution of DOTS TB cases in Santiago de Compostela by year and type of tuberculosis

Year	New TB cases N°/% DOTS	Retreatment cases			Total Nª/% DOTS/%
		Treatment after default N°/% DOTS	Relapse N/% DOTS	Chronic N°/% DOTS
1996–2000	1263/90.6	29/2.1	98/7	4/0.3	1394/56.8
	94	26	24	4	148
2001–2006	997/93.9	7/0.7	58/5.4	0	1062/43.2
	85	5	21	0	111
Total	2260/92	36/1.5	156/6.4	4/0.2	2456/100
	179	31	45	4	259/10.5

Abbreviations: DOTS, directly observed therapy, short course; TB, tuberculosis; N, number of cases.

Table 2 DOTS treatment locations

Place of treatment	N° DOTS	%
UTB	97	37.5
Health center	72	27.8
Social services	42	16.2
Family	31	12
Drugs unit	13	5
School	3	1.2
Hospital	1	0.4

Abbreviation: DOTS, directly observed therapy, short course; UTB, tuberculosis unit at Santiago de Compostela University Hospital, Spain.

Table 3 Patterns and treatment regimen for tuberculosis

Standard treatment	Treatment after
	Regimen	New	Default	Relapsed	Chronic
2HRZ + 4HR	Daily	85	8	4	–
	Twice/week	2	1	–	–
2HRZE + 4HR	Daily	32	10	16	–
	Twice/week	3	–	–	–
2Rbhz + 4RbH	Daily	–	1	–	–
2HRE + 7RH	Daily	8	1	1	–
2HRZES + 1HRES + 5HRE	Daily	5	–	8	–
Prolonged stándard treatment
2HRZ + 10 HR	Daily	2	1	–	–
2HRZ + 7HR	Daily	4	2	1	–
2HRZE + 10HR	Daily	8	1	1	–
2HRZE + 7HR	Daily	1	1	–	–
2HRE + 10HR	Daily	7	2	2	–
2HRSZ + 10HR	Daily	–	–	2	–
Other treatments
Resistant TB/multiresistant or intolerances
2HRZE + 10RE	Daily	2	1	1	–
2HRZ + 10RE	Daily	4	–	–	–
2HZE + 16HE	Daily	1	–	–	–
2REZS + 10RE	Daily	–	–	1	–
Treatment with first-line drugs + quinolones	Daily	8	1	2	–
Treatment with first-line drugs + quinolones + other second line drugs	Daily	5	1	6	3
Other treatments with first- and second-line drugs	Daily	2	–	–	1

Abbreviations: TB, tuberculosis; H, isoniazid; R, rifampicin; E, ethambutol; Z, pyrazinamide; S, streptomycin; Rb, rifabutin.

Table 4 Final status of tuberculosis cases after DOTS

Final status of the case	New TB/%	Retreatment TB/%	Total/%
Bacteriological cure	7/3.9	5/6.2	12/4.6
Treatment completed	151/84.4	62/77.5	213/82.2
Defaulted	8/4.5	2/2.5	10/4
Death from TB	0	2/2.5	2/0.8
Death from other causes	6/3.4	5/6.3	11/4.2
Transferred out	7/3.8	4/5	11/4.2
Total	179/69.1	80/30.8	259

Abbreviations: DOTS, directly observed therapy, short course; TB, tuberculosis.