Overview of ^99mTc-anti-TNF-α scintigraphy: diagnostic applications

Figures & data

Table 1 Summary of research performed with ^99mTc-Anti-TNF-α scintigraphy

Study	Radiopharmaceutical	Experimental/clinical	Number of cases	Disease	Results
Conti et al^Citation5	^99^mTc infliximab	Clinical	Case reports	Spondylarthropathy	It is a guide for evaluation and prognosis
Chianelli et al^Citation6	^99^mTc infliximab	Clinical	7 patients	Rheumatoid arthritis	It is important for more detailed diagnosis
D’Alessandria et al^Citation7	^99^mTc infliximab	Experimental/clinical	9 mice, 10 patients	Crohn’s disease	Tumor necrosis factor-α mechanism of action should be known for therapy decision
Barrera et al^Citation11	^99^mTc adalimumab	Clinical	10 patients	Rheumatoid arthritis	It is specific for treatment and inflamed joints evaluation
Malviya et al^Citation12	^99mTc infliximab and ^99mTc adalimumab	Clinical	19 patients	Rheumatoid arthritis	Therapy evaluation with tumor necrosis factor-α is better than other scintigraphic imaging
Lopes et al^Citation14	^99mTc-anti-tumor necrosis factor-α monoclonal antibody	Clinical	Case report	Graves ophthalmopathy	New target-based modalities for diagnosis and therapy
Malviya et al^Citation13	^99mTc infliximab	Clinical	20 patients	Chronic inflammatory autoimmune diseases	For cost effectiveness, scintigraphic imaging is needed

Conti F, Priori R, Chimenti MS, et al. Successful treatment with intraarticular infliximab for resistant knee monarthritis in a patient with spondylarthropathy: a role for scintigraphy with 99mTc-infliximab. Arthritis Rheum. 2005;52(4):1224–1226.

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Chianelli M, D’Alessandria C, Conti F, et al. New radiopharmaceuticals for imaging rheumatoid arthritis. Q J Nucl Med Mol Imaging. 2006;50(3):217–225.

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D’Alessandria C, Malviya G, Viscido A, et al. Use of a 99mTc labeled anti-TNFalpha monoclonal antibody in Crohn’s disease: in vitro and in vivo studies. Q J Nucl Med Mol Imaging. 2007;51(4):334–342.

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Barrera P, Oyen WJ, Boerman OC, van Riel PL. Scintigraphic detection of tumour necrosis factor in patients with rheumatoid arthritis. Ann Rheum Dis. 2003;62(9):825–828.

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Malviya G, Conti F, Chianelli M, Scopinaro F, Dierckx RA, Signore A. Molecular imaging of rheumatoid arthritis by radiolabelled monoclonal antibodies: new imaging strategies to guide molecular therapies. Eur J Nucl Med Mol Imaging. 2010;37(2):386–398.

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Lopes FP, de Souza SA, Dos Santos Teixeira Pde F, et al. 99mTc-Anti-TNF-α scintigraphy: a new perspective within different methods in the diagnostic approach of active Graves ophthalmopathy. Clin Nucl Med. 2012;37(11):1097–1101.

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Malviya G, Anzola KL, Podestà E, et al. (99m)Tc-labeled rituximab for imaging B lymphocyte infiltration in inflammatory autoimmune disease patients. Mol Imaging Biol. 2012;14(5):637–646.

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