Synonymous codons influencing gene expression in organisms

Figures & data

Figure 1 Relation between synonymous mutation and cotranslational protein folding: its effects on various factors controlling translation speed.

Abbreviations: mRNA, messenger RNA; tRNA, transfer RNA.

Figure 2 Relation between codon usage bias, speed of ribosome on mRNA, and protein folding kinetics.

Abbreviation: mRNA, messenger RNA.

Figure 3 A simplified model based on recent experimental data.

Notes: Adapted from Molecular Cell, Vol 61/edition 3, Buhr F, Jha S, Thommen M, et al, Synonymous codons direct cotranslational folding toward different protein conformations, Pages 341–351, Copyright 2016, with permission from Elsevier.⁷²

Abbreviations: Cys, cysteine; s, seconds.

Buhr F, Jha S, Thommen M, et al. Synonymous codons direct cotranslational folding toward different protein conformations. Mol Cell. 2016;61(3):341–351.

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