Imbalance in extracellular matrix degradation in urethral stricture

Figures & data

Table 1 Proportions of total collagen in control and urethral stricture groups by observation time

Observation day	Control (%) Median (range)	Urethral stricture (%) Median (range)
Day 7	54.25 (47.4–61.1)	31.25 (23.0–39.5)
Day 14	51 (43.9–58.1)	44.2 (27.8–60.6)
Day 21	53.5 (48.1–58.9)	51.25 (33.2–69.3)
Day 28	51.45 (41.9–61.0)	57.75 (47.0–68.5)
Day 56	60.95 (54.7–67.2)	61.5 (48.4–74.6)

Figure 1 MMP1 levels in the urethral stricture group were lower than the control group on days 21 and 28.

Table 2 MMP1 levels in urethra stricture and control groups by observation time

Observation day	Control (%) Median (range)	Urethral stricture (%) Median (range)
Day 7	2.32 (2.15–2.50)	2.5 (2.25–2.75)
Day 14	2.47 (2.25–2.70)	2.47 (2.30–2.65)
Day 21	2.9 (2.45–3.35)	2.5 (2.35–2.65)
Day 28	4.1 (3.50–4.70)	3.12 (2.55–3.70)
Day 56	3.02 (2.30–3.75)	3.35 (3.10–3.60)

Table 3 TIMP1 levels in urethral stricture and control groups by observation time

Observation day	Control (%) Median (range)	Urethral stricture (%) Median (range)
Day 7	0.925 (0.25–1.6)	0.17 (0.04–0.3)
Day 14	0.125 (0.07–0.18)	0.145 (0.01–0.28)
Day 21	0.055 (0.04–0.07)	3.65 (0.22–7)
Day 28	1.035 (0.07–2)	4.015 (0.23–7.8)
Day 56	0.215 (0.05–0.38)	1.445 (0.19–2.7)

Figure 2 TIMP1 levels were higher in the urethral stricture group than the control group on days 21, 28, and 56.