The Protective Effect of Lycopene on Prostate Growth Inhibitory Efficacy by Decreasing Insulin Growth Factor-1 in Indonesian Human Prostate Cancer Cells

Figures & data

Figure 1 Grouping of lycopene treatment in human prostate cancer cell culture.

Figure 2 Average IGF-1 level on various lycopene concentrations and observation time.

Table 1 Average IGF-1 Level Based on Lycopene Concentrations and Observation Time

Treatment group	Observation Time (hour)	Average (SD) (ng/mL)	Range (ng/mL)	F test
Group A	24	0.112 (0.0)	0.112	F count (treatment group) = 3870,558; p=0.000 (p<0.05) F count (observation time) = 1955,481;p=0.000 (p<0.05)
	48	0.113 (0.0028)	0.111‒0.115
	72	0.1125 (0.0007)	0.112‒0.113
Group B	24	0.112 (0.0)	0.112
	48	0.112 (0.0)	0.112
	72	0.113 (0.0)	0.113
Group C	24	0,.115 (0.0049)	0.108–0.115
	48	0.112 (0.0028)	0.110–0.114
	72	0.112 (0.0)	0.112
Group D	24	0.112 (0.0)	0.112
	48	0.760 (0.0141)	0.750–0.770
	72	0.690 (0.0)	0.690
Group E	24	0.785 (0.0212)	0.770–0.800
	48	0.680 (0.0)	0.680
	72	0.515 (0.0212)	0.530–0.630

Table 2 Difference in Average of IGF-1 Level from Combination Treatment Based on Factorial Scheme Analysis

Treatment Group	Observation Time (hour)	Average (SD) (ng/mL)	Range (ng/mL)
1. Group A 2. Group B 3. Group C 4. Group D 5. Group E Combination	24 Hour 48 Hour 72 Hour Combination 24 Hour 48 Hour 72 Hour Combination 24 Hour 48 Hour 72 Hour Combination 24 Hour 48 Hour 72 Hour Combination 24 Hour 48 Hour 72 Hour Combination 24 Hour 48 Hour 72 Hour	0.112 (0.0) 0.113 (0.0028) 0.1125 (0.0007) 0.1125 (0.0014) (a) 0.112 (0) 0.112 (0) 0.113 (0) 0.1123 (0.0005) (a) 0.1115 (0.0049) 0.112 (0.0028) 0.112 (0) 0.1118 (0.0026) (a) 0.112 (0) 0.760 (0.0141) 0.690 (0) 0.5207 (0.3181) (b) 0.785 (0.0212) 0.680 (0) 0.580 (0.0707) 0.6817 (0.0974) (c) 0.2465 (0.2839) (A) 0.3554 (0.3150) (B) 0.3215 (0.2733) (C)	0.112 0.111–0.115 0.112–0.113 0.111–0.115 0.112 0.112 0.113 0.112–0.113 0.108–0.115 0.110–0.114 0.112 0.108–0.115 0.112 0.750–0.770 0.690 0.112–0.770 0.770–0.800 0.680 0.530–0.630 0.530 –0.800 0.112–0.785 0.112–0.760 0.1125–0.690