Pharmacological enhancement of naltrexone treatment for opioid dependence: a review

Figures & data

Table 1 Naltrexone and buprenorphine: opioid receptor activity profiles

	Receptor binding Kior IC50
	μ	κ	δ	ORL-1
Naltrexone	0.37	4.8	9.4	3,818a
Buprenorphine	0.77	1.1	2.2	8.4b

Notes: Unless otherwise noted, values are from Schmidt et al.⁴⁶

a McLeod et al;⁴⁷

b Wnendt et al.⁴⁸

SchmidtWKTamSWShotzbergerGSSmithDHJrClarkRVernierVGNalbuphineDrug Alcohol Depend1985143–43393622986929

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McLeodRLParraLEMutterJCNociceptin inhibits cough in the guinea-pig by activation of ORL(1) receptorsBr J Pharmacol200113261175117811250866

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WnendtSKrugerTJanochaEHildebrandtDEnglbergerWAgonistic effect of buprenorphine in a nociceptin/OFQ receptor-triggered reporter gene assayMol Pharmacol199956233433810419552

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