Mesenchymal and induced pluripotent stem cells: general insights and clinical perspectives

Figures & data

Table 1 General characteristics of mesenchymal and induced pluripotent stem cells

	MSC	iPS cells
Morphology	Fibroblastic-like^Citation25	Embryonic stem cell-like^Citation17
Phenotype	CD29+, CD44+, CD73+, CD90+, CD105+, CD166+, CD14−, CD31−, CD45−, CD34−^Citation37	OCT4+, NANOG+, SOX2+, SSEA1+, SSEA3+, SSEA4+, TRA1-60+, TRA1-81+, ALP+^Citation58^–^Citation60
Plasticity	Multipotents^Citation18	Pluripotents^Citation17,Citation45
Differentiation potential	Mesodermal tissues^Citation14,Citation26	Endodermal, mesodermal, and ectodermal tissues^Citation25
Tumorigenesis	No^Citation30^–^Citation32	Yes^Citation25

Abbreviations: MSC, mesenchymal stem cells; iPS, induced pluripotent stem.

Figure 1 Potential application of MSC and iPS cells in preclinical and clinical transplantation.

Notes: MSC are nontumorigenic, therefore, they are safe to be transplanted systematically or locally. On the other hand, the pluripotency state of iPS cells can mean a wide possibility of disease treatment, and their pre-differentiation in vitro can guarantee the safeness of utilization.
Abbreviations: MSC, mesenchymal stem cells; iPS, induced pluripotent stem.

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