Figures & data
Figure 1 The translocation t(11;14)(q13;q32) is a nonrandom chromosomal rearrangement in Mantle cell lymphoma.
Figure 2 The frequent karyotype abnormalities in CLL are not mutually exclusive. Representative G-banded karyotype of a CLL showing deletions of the long arm of chromosome 11 as well as of chromosome 13: 46,XX,del(11)(q21),del(13)(q14).
Figure 3 Deletions of chromosome 13 are the most frequent karyotype alterations in CLL. (A, left to right): Ideogram of chromosome 13, example of an interstitial deletion of the long arm of chromosome 13 in CLL, and example of a terminal deletion of chromosome 13 in CLL. (B) Part of a metaphase with monoallelic deletion of chromosome 13 as detected by FISH, the orange (spectrum: orange)-labeled probe detects the minimal deleted region, the green (spectrum: green)-labeled probe detects a terminal DNA segment of the long arm of chromosome 13 to facilitate its identification. Chromosomes are counterstained by DAPI. (C) Part of a metaphase with diallelic deletion of chromosome 13 as detected by FISH. For probes and counterstaining see (B). (D, left to right): nucleus of a normal cell without 13q-deletion and nucleus of a cell with biallelic deletion. For probes and counterstaining see (B).
Figure 4 Trisomy 12 is the second most frequent karyotypic abnormality seen in CLL. Representative G-banded karyotype of a CLL with trisomy 12 as the sole karyotypic deviation. Karyotype: 47,XY,+12.
Figure 5 Partial karyotypes showing recurrent chromosomal deletions in CLL. (A) Chromosomal pair 11 from a CLL showing a del(11)(q22). (B) Chromosomal pair 17 from a CLL showing a del(17)(p12). (C) Chromosomal pair 6 from a CLL showing a del(6)(q13q22).
Figure 6 Complex aberrant karyotypes in CLL are associated with an adverse prognosis. Example of a CLL with a complex karyotypic rearrangement involving chromosomes 3, 4, 13, 14, 15, and 16. Karyotype: 47,XY,der(3)t(3;15)(q21;q22),t(4;16)(q31;q24),+12,del(13)(q14),der(14)t(3;14)(q21;q24),der(15)t(13;15)(q14;q22). (A) Representative G-banded karyotype. (B) SKY-FISH analysis.
