HLA-DQA1 and HLA-DQB1 Gene Polymorphism in Indonesian Children with Type I Diabetes Mellitus

Figures & data

Figure 1 (A) Electrophoresis result from PCR-RFLP of HLA-DQA1 with Rsa1 restriction enzyme in T1DM groups. (B) Electrophoresis result from PCR-RFLP of HLA-DQA1 with Rsa1 restriction enzyme in control groups.

Table 1 Baseline Characteristics of the Subjects in This Study

Characteristics	N = 31
	T1DM		Control
	N	%	N	%
Gender
Boys	19	61.3%	16	51.6%
Girls	12	38.7%	15	48.4%
Ethnicity
Javanese	27	87.1%	31	100%
Madurese	1	3.2%	0	0
Chinese	1	3.2%	0	0
Malay	2	6.4%	0	0
	N	Mean ± SD	N	Mean ± SD
Age (years)	31	15.05 ± 3.9	31	10.58 ± 2.40
Height (m)	31	1.46 ± 0.19	31	1.29 ± 0.15
Weight (kg)	31	42.62 ± 14.35	31	30.13 ± 11.87
BMI	31	19.37 ± 4.46	31	17.26 ± 3.25

Table 2 Distribution of HLA-DQA1 Polymorphisms in the T1DM and Control Groups

Polymorphism	T1DM (%)	Control (%)	p
01	5 (16.1)	1 (3.2)	0.09
03	1 (3.2)	2 (6.5)	0.50
04	2 (6.5)	12 (38.7)	0.00
0103	17 (54.8)	18 (58.1)	0.79
0601	19 (61.3)	22 (71.0)	0.42
0101/0102	21 (67.6)	15 (48.4)	0.12
0401/0501	10 (32.3)	2 (6.5)	0.01
01/03	2 (6.5)	0 (0)	0.25
01/04	0 (0)	2 (6.5)	0.25
02/03	2 (6.5)	0 (0)	0.25
03/01	1 (3.2)	2 (6.5)	0.50
03/04	7 (22.6)	4 (12.9)	0.32
01/02/03	2 (6.5)	3 (9.7)	0.50
01/03/01	0 (0)	4 (12.9)	0.06
01/03/04	9 (29.0)	1 (3.2)	0.01

Table 3 Distribution HLA-DQB1 Polymorphisms in the T1DM and Control Groups

Polymorphism	T1DM (%)	Control (%)	p
0201	5 (16.1)	5 (16.1)	1.00
0301	17 (54.8)	18 (58.1)	0.79
0302	15 (48.4)	3 (9.7)	0.00
0303	15 (48.4)	17 (54.8)	0.61
0401	31 (100)	31 (100)	–
0402	31 (100)	31 (100)	–
0403	0 (0)	1 (3.2)	0.50
0501	31 (100)	31 (100)	–
0502	10 (32.3)	21 (67.7)	0.01
0503	31 (100)	31 (100)	–
0601	31 (100)	31 (100)	–
0602	15 (48.4)	10 (32.3)	0.19
0603	15 (48.4)	10 (32.3)	0.19
0604	31 (100)	31 (100)	–