The genetic basis of ankylosing spondylitis: new insights into disease pathogenesis

Figures & data

Table 1 Summary of ankylosing spondylitis-susceptibility genes identified by genome-wide association studies

RUNX3	Runt-related transcription factor 3
IL23R	Interleukin 23 receptor
IL12Rβ2	Interleukin 12 receptor, β2
GRP25	G-protein-coupled receptor 25
KIF21B	Kinesin family member 21B
PTGER4	Prostaglandin E receptor 4 (subtype EP4)
ERAP1	Endoplasmic reticulum aminopeptidase 1
ERAP2	Endoplasmic reticulum aminopeptidase 2
LNPEP	Leucyl/cystinyl aminopeptidase
IL12B	Interleukin 12B
CARD9	Caspase recruitment-domain family member 9
LTβR	Lymphotoxin β-receptor (TNFR superfamily, member 3)
TNFRSF1A	Tumor-necrosis factor-receptor superfamily member 1A
NPEPPS	Aminopeptidase puromycin-sensitive
TBkBP1	TNFR-associated factor family member-associated nuclear factor-κB-binding kinase 1-binding protein
TBX21	T-box 21
IL6R	Interleukin 6 receptor
FCGR2A	Fc fragment of immunoglobulin G, low-affinity IIa, receptor (CD32)
UBE2E3	Ubiquitin-conjugating enzyme E2E 3
GPR35	G-protein-coupled receptor 35
NKX2-3	NK2 homeobox 3
ZMIZ1	Zinc finger, MIZ type-containing 1
SH2B3	Src homology 2B adaptor protein 3
GPR65	G-protein-coupled receptor 65
IL27	Interleukin 27
SULT1A1	Sulfotransferase family cytosolic 1A
TYK2	Tyrosine kinase 2
ICOSLG	Inducible T-cell costimulator ligand
EOMES	Eomesodermin
IL7R	Interleukin 7 receptor
BACH2	BTB and CNC homology 1, basic leucine-zipper transcription-factor 2

Abbreviation: CD, classification determinant.

Figure 1 Summary of family-based association analyses using multiplex ankylosing spondylitis (AS) families from the North American Spondylitis Consortium (NASC).

Abbreviations: ANKH, human homolog of progressive ankylosis; TNAP, tissue-nonspecific alkaline phosphatases.