Impact of preoperative chronic renal failure on liver transplantation: a population-based cohort study

Figures & data

Figure 1 Study design and flowchart for patient selection.

Abbreviations: LT, liver transplant; CRF, chronic renal failure.

Table 1 General demographics of the study subjects with or without CRF preoperatively

Characteristics	With CRF (n=123)	Without CRF (n=2,808)	P-value
Age (mean [SD])	46.76 (18.80)	46.42 (17.65)	0.8356
Gender			0.1893
Female	30 (24.39)	840 (29.91)
Male	93 (75.61)	1,968 (70.09)
Preoperative clinical parameters
Hypertension	44 (35.77)	556 (19.80)	<0.0001
Pulmonary diseases	23 (18.70)	397 (14.14)	0.1576
Diabetes mellitus	42 (34.15)	571 (20.33)	0.0002
Cerebrovascular disease	8 (6.50)	87 (3.10)	0.0597
Coronary heart disease	14 (11.38)	190 (6.77)	0.0490
Congestive heart failure	6 (4.88)	44 (1.57)	0.0169
Vascular disease	1 (0.81)	16 (0.57)	0.5185
Chronic hepatitis
Alcoholic hepatitis	35 (28.46)	523 (18.63)	0.0066
Hepatitis B	58 (47.15)	1,353 (48.18)	0.8231
Hepatitis C	22 (17.89)	502 (17.88)	0.9980
Esophageal varices	38 (30.89)	1,029 (36.65)	0.1945

Notes: Chi-squared test, t-test, or Fisher’s exact test was used to examine the differences in the demographic characteristics of liver transplant recipients. Values presented as n (%) unless otherwise indicated.

Abbreviations: CRF, chronic renal failure; SD, standard deviation.

Figure 2 Unadjusted Kaplan–Meier survival curves of patient survival during the first year after liver transplantation.

Abbreviation: CRF, chronic renal failure.

Figure 3 Unadjusted Kaplan–Meier survival curves of patient survival 14.5 years after liver transplantation.

Abbreviation: CRF, chronic renal failure.

Table 2 Outcome characteristics of liver transplant recipients with or without CRF

Characteristics	With CRF (n=123)	Without CRF (n=2,808)	P-value
ICU stay (days), mean (SD)	15.56 (16.30)	16.01 (17.12)	0.7777
Hospital stay (days), mean (SD)	48.80 (32.64)	48.47 (34.99)	0.9198
Bacteremia, n (%)	8 (6.50)	156 (5.56)	0.6542
Pneumonia, n (%)	3 (2.44)	83 (2.96)	1.0000
Postoperative bleeding, n (%)	4 (3.25)	146 (5.20)	0.3374

Note: Chi-squared test, t-test, or Fisher’s exact test was used to examine the differences of liver transplant recipients.

Abbreviations: CRF, chronic renal failure; SD, standard deviation; ICU, intensive care unit.

Table 3 Post-liver transplant morbidities of liver transplant recipients with or without CRF

Characteristics	With CRF (n=123)		Without CRF (n=2,808)		P-value
	n	%	n	%
Cerebrovascular disease	0	0.00	44	1.57	0.2601
Coronary heart disease	2	1.63	82	2.92	0.7735

Note: Chi-squared test, t-test, or Fisher’s exact test was used to examine the differences in post-liver transplant morbidities of liver transplant recipients.

Abbreviation: CRF, chronic renal failure.