Assessment of isoniazid preventive therapy in the reduction of tuberculosis among ART patients in Arba Minch Hospital, Ethiopia

Figures & data

Table 1 Sociodemographic characteristics of study participants on ART with prophylaxis status in Arba Minch hospital, 2010

Sociodemographic characteristics	Group	IPT group number (%)	Non-IPT group number (%)	Total number (%)
Age	0–14 yr	18 (13.0)	8 (6.0)	26 (9.6)
	15–24 yr	13 (9.4)	13 (9.8)	26 (9.6)
	25–34 yr	52 (37.6)	60 (45.1)	112 (41.3)
	≥35 yr	50 (36.2)	57 (42.8)	107 (39.5)
Sex	Male	48 (34.7)	64 (48.1)	112 (41.3)
	Female	90 (65.3)	69 (51.9)	159 (58.7)
Religion	Orthodox	83 (60.1)	93 (70.0)	176 (64.9)
	Protestant	37 (26.8)	35 (26.3)	72 (26.6)
	Others	13 (9.4)	10 (7.5)	23 (8.4)
Educational status	Illiterate	53 (38.4)	40 (30.0)	93 (34.3)
	Primary	48 (34.7)	47 (35.3)	95 (35.1)
	Secondary and above	32 (23.1)	51 (38.3)	83 (25.8)
Marital status	Single	31 (21.7)	30 (23.3)	61 (22.5)
	Married	76 (53.6)	74 (57.1)	150 (55.4)
	Others	31 (22.4)	29 (21.8)	60 (22.1)
Total		138 (50.9)	133 (49.1)	271 (100)

Abbreviations: ART, antiretroviral therapy; IPT, isoniazid prevention therapy; yr, year.

Table 2 Association of sociodemographic characteristics with TB status in IPT group in Arba Minch hospital, 2010

Sociodemographic characteristics	Groups	IPT group (n=138)		RR (95% CI)
		TB positive number (%)	TB negative number (%)
Sex	Male	5 (10.4)	43 (89.6)	1.00
	Female	7 (7.8)	83 (92.2)	0.75 (0.25, 2.23)
Age	0–14 yr	1 (12.5)	7 (87.75)	1.00
	15–24 yr	1 (7.7)	12 (92.3)	0.62 (0.04, 8.52)
	25–34 yr	3 (5.0)	57 (95.0)	0.40 (0.05, 3.4)
	≥35 yr	7 (12.3)	50 (87.7)	0.98 (0.14, 6.98)
Marital status	Single	3 (9.7)	28 (90.3)	1.00
	Married	5 (6.6)	71 (93.4)	0.68 (0.17, 2.67)
	Others	4 (12.9)	27 (87.1)	1.33 (0.32, 5.47)
Educational status	Illiterate	3 (7.5)	37 (92.5)	1.00
	Primary	7 (14.9)	40 (85.1)	2.15 (0.51, 8.96)
	Secondary and above	2 (3.9)	49 (96.1)	0.52 (0.09, 2.98)
Religion	Orthodox	9 (9.7)	84 (90.3)	1.00
	Protestant	2 (5.7)	33 (94.3)	0.59 (0.13, 2.60)
	Others	1 (10.0)	49 (90.0)	1.03 (0.15, 7.34)
Total		12 (8.7)	126 (91.3)

Abbreviations: CI, confidence interval; TB, tuberculosis; IPT, isoniazid prevention therapy; RR, relative risk; yr, year.

Table 3 Association of sociodemographic characteristics with TB status in non-IPT group in Arba Minch hospital, 2010

Sociodemographic characteristics	Groups	Non-IPT group (n=133)		RR (95% CI)
		TB positive number (%)	TB negative number (%)
Sex	Male	19 (29.7)	45 (70.3)	1.00
	Female	18 (26.1)	51 (73.9)	0.88 (0.51, 1.52)
Age	0–14 yr	6 (33.3)	12 (66.7)	1.00
	15–24 yr	4 (30.8)	9 (69.2)	0.92 (0.32, 2.62)
	25–34 yr	13 (25.0)	39 (75.0)	0.75 (0.34, 1.68)
	≥35 yr	14 (28.0)	36 (72.0)	0.84 (0.38, 1.85)
Marital status	Single	9 (30.0)	21 (70.0)	1.00
	Married	17 (23.0)	57 (77.0)	0.77 (0.38, 1.52)
	Others	11 (37.9)	18 (62.1)	1.26 (0.62, 2.59)
Educational status	Illiterate	15 (28.3)	38 (71.7)	1.00
	Primary	14 (29.2)	34 (70.8)	1.03 (0.56, 1.96)
	Secondary and above	8 (25.0)	24 (75.0)	0.88 (0.42, 1.85)
Religion	Orthodox	21 (25.3)	62 (74.4)	1.00
	Protestant	9 (6.7)	28 (21.0)	0.96 (0.49, 1.89)
	Others	7 (53.8)	6 (46.2)	2.13 (1.14, 3.97)
Total		37 (27.8)	96 (72.2)

Abbreviations: CI, confidence interval; TB, tuberculosis; IPT, isoniazid prevention therapy; RR, relative risk; yr, year.

Table 4 TB status with prophylaxis type used among patients on ART in Arba Minch hospital, 2010

Type of prophylaxis	AFB smear result		RR (95% CI)
	Positive number (%)	Negative number (%)
IPT group	12 (8.7)	126 (91.3)	0.32 (0.122, 0.49)
Non-IPT group	37 (27.8)	96 (72.2)
Total	49 (18.0)	222 (82.0)

Abbreviations: ART, antiretroviral therapy; AFB, acid-fast bacillus; CI, confidence interval; TB, tuberculosis; IPT, isoniazid prevention therapy; RR, relative risk.

Table 5 Mean CD4⁺ count change, with prophylaxis type, among ART users from Arba Minch hospital, Ethiopia, 2010

Period	IPT group (n=86)	Non-IPT group (n=54)	P-value
Mean CD4^+ count (SD)	267.66 (146.59)	252.41 (179.41)	0.5
At the baseline
Mean CD4^+ count (SD)	389.55 (221.09)	346.04 (245.32)	0.2
After 6 mo
P-value	0.00	0.01

Abbreviations: ART, antiretroviral therapy; IPT, isoniazid preventive therapy; SD, standard deviation; mo, month.