Everolimus for the treatment of refractory seizures associated with tuberous sclerosis complex (TSC): current perspectives

Figures & data

Table 1 Current recommendations on epilepsy treatment in TSC patients. Data from Curatolo et al¹⁰ and Curatolo et al.¹¹

Epilepsy syndrome	First line	Second line	Third line	Fourth line
West syndrome (infants)	Vigabatrin	Steroids (ACTH/prednisolone)	Ketogenic diet	AED combination
Focal seizures in infants (with or without secondary generalization)	Vigabatrin	Topiramate Carbamazepine Oxcarbazepine	Consider epilepsy surgery	Ketogenic diet AED combination
Focal seizures in patients >2 years (with or without secondary generalization)	Carbamazepine Oxcarbazepine Topiramate	Consider epilepsy surgery, if not an option try second AED	Everolimus	Consider AED combination ketogenic diet VNS

Abbreviations: AED, antiepileptic drug; VNS, vagal nerve stimulation; ACTH, adrenocorticotropic hormone.

Curatolo P, Nabbout R, Lagae L, et al. Management of epilepsy associated with tuberous sclerosis complex: updated clinical recommendations. Eur J Paediatr Neurol. 2018;22(5):738–748. doi:10.1016/j.ejpn.2018.05.00629880258

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Curatolo P, Jóźwiak SNabbout R. TSC consensus meeting forSEGA and epilepsy management. management of epilepsy associated with tuberous sclerosis complex (TSC): clinicalrecommendations. Eur J Paediatr Neurol. 2012;16(6): doi:10.1016/j.ejpn.2012.05.004

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