Effects of sevoflurane versus propofol on cerebrovascular reactivity to carbon dioxide during laparoscopic surgery

Figures & data

Table 1 Characteristics of patients

Variables	Sevoflurane group (n=44)	Propofol group (n=44)	P-value
Age (years)	45.07±12.12	44.20±12.87	0.353
Sex (M/F)	22/22	21/23	0.831
BMI (kg/m^2)	24.64±3.75	24.28±3.17	0.220
ASA grade (I/II)	34/10	35/9	0.796
Anesthesia duration (min)	65.05±7.05	66.40±4.60	0.750
Fluid infusion (mL)	500.65±276.93	500.74±280.05	0.643

Note: Data presented as mean ± SD.

Abbreviations: M, male; F, female; BMI, body mass index; ASA, American Society of Anesthesiologists.

Table 2 CVR-CO₂ before and during pneumoperitoneum compared with baseline

Group	Baseline	Before pneumoperitoneum	During pneumoperitoneum
Sevoflurane group (n=44)	3.76 (2.56, 5.07)	4.63 (3.59, 6.95)**	4.29 (2.98, 6.32)*
Propofol group (n=44)	4.04 (2.97, 5.09)	4.67 (3.56, 6.12)*	3.91 (3.47, 6.00)

Notes: Data presented as median (first quartile, third quartile); the unit of Vmean-CO₂ is %/mmHg.

* P<0.05,

** P<0.01 in comparison with baseline.

Abbreviation: CVR-CO₂, cerebrovascular reactivity to carbon dioxide.

Table 3 MBP before and during pneumoperitoneum compared with baseline

Group	Baseline	Before pneumoperitoneum	During pneumoperitoneum
Sevoflurane group (n=44)	85 (90, 93)	78 (71, 84)**	85 (77, 93)
Propofol group (n=44)	88 (81, 98)	79 (73, 89)**	90 (84, 97)

Notes: Data presented as median (first quartile, third quartile); the unit of MBP is mmHg.

** P<0.01 in comparison with baseline.

Abbreviation: MBP, mean blood pressure.

Table 4 Correlations between MBP and CVR-CO₂

Group	Baseline	Before pneumoperitoneum	During pneumoperitoneum
Sevoflurane group (n=44)	−0.009	−0.014	0.017
Propofol group (n=44)	0.036	0.095	−0.044

Abbreviations: CVR-CO₂, cerebrovascular reactivity to carbon dioxide; MBP, mean blood pressure.

Table 5 Comparisons of MMSE scores at different time points

Group	Baseline	24 hours after surgery
Sevoflurane group (n=44)	29 (28, 29)	28 (28, 29)
Propofol group (n=44)	28 (28, 29)	28 (27, 29)

Note: Data presented as median (first quartile, third quartile).

Abbreviation: MMSE, Mini-Mental State Examination.