Positive correlation of the serum angiopoietin-like protein 3 levels with the aortic augmentation index in patients with coronary artery disease

Figures & data

Table 1 Clinical and analytical characteristics of 100 patients with coronary artery disease

Items	Parameter	Values	Parameter	Values
Anthropometric data	Age (years)	65.41±9.05	Height (cm)	160.82±8.35
	Body weight (kg)	68.04±11.79	Body mass index (kg/m^2)	26.21±3.35
	Aortic augmentation index (%)	24.17±9.43	SBP (mmHg)	130.98±16.80
	DBP (mmHg)	72.46±10.31
Biochemical data	White blood count (×1,000/µL)	6.43±1.64	Hemoglobin (g/dL)	14.25±1.52
	Triglyceride (mg/dL)	119.00 (90.25–162.00)	Total cholesterol (mg/dL)	164.57±35.93
	HDL-C (mg/dL)	44.90±11.79	LDL-C (mg/dL)	95.01±26.27
	Fasting glucose (mg/dL)	111.50 (97.00–145.25)	Creatinine (mg/dL)	1.10 (0.90–1.30)
	Blood urea nitrogen (mg/dL)	16.00 (13.00–19.00)	eGFR (mL/min)	68.36±19.30
	Total calcium (mg/dL)	9.13±0.37	Phosphorus (mg/dL)	3.55±0.52
	iPTH (pg/mL)	52.94±27.79	ANGPTL3 (ng/mL)	246.02 (148.86–307.20)

Note: Values for continuous variables given as mean ± SD and variables not normally distributed given as medians and interquartile range.

Abbreviations: DBP, diastolic blood pressure; SBP, systolic blood pressure; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; eGFR, estimated glomerular filtration rate; iPTH, intact parathyroid hormone; ANGPTL3, angiopoietin-like protein 3.

Table 2 Clinical characteristics and AIx levels of 100 patients with coronary artery disease

Characteristic	Number	AIx (%)	P-value
Gender			0.003*
Male	74	22.55±8.30
Female	26	28.77±11.02
Diabetes			0.204
No	53	23.04±10.44
Yes	47	25.45±8.06
Hypertension			0.366
No	23	25.74±10.58
Yes	77	23.70±9.08
Angiotensin-converting enzyme inhibitor			0.422
No	70	23.67±9.11
Yes	30	25.33±10.21
Angiotensin-receptor blocker			0.595
No	61	24.57±10.38
Yes	39	23.54±7.81
β blocker			0.533
No	43	23.49±8.78
Yes	57	24.68±9.94
Calcium-channel blocker			0.163
No	68	23.26±9.70
Yes	32	26.09±8.68
Statin			0.341
No	34	22.91±11.67
Yes	66	24.82±8.07
Fibrate			0.110
No	86	24.78±9.25
Yes	14	20.43±10.05

Note:

* P<0.05 was considered statistically significant after the Student’s independent t-test.

Abbreviation: AIx, augmentation index.

Table 3 Correlation of AIx levels and clinical variables by univariate linear regression analysis among 100 patients with coronary artery disease

Variable	r-value	P-value
Age (years)	0.202	0.044*
Height (cm)	−0.363	<0.001*
Body weight (kg)	−0.350	<0.001*
Body mass index (kg/m^2)	−0.181	0.071
Systolic blood pressure (mmHg)	0.157	0.120
Diastolic blood pressure (mmHg)	0.095	0.347
White blood count (×1,000/µL)	0.110	0.275
Hemoglobin (g/dL)	−0.107	0.289
Total cholesterol (mg/dL)	0.036	0.721
Log-TG (mg/dL)	0.046	0.649
HDL-C (mg/dL)	−0.060	0.556
LDL-C (mg/dL)	0.089	0.376
Log-glucose (mg/dL)	0.030	0.768
Log-BUN (mg/dL)	−0.044	0.661
Log-Cre (mg/dL)	−0.126	0.211
eGFR (mL/min)	0.010	0.922
Total calcium (mg/dL)	0.062	0.542
Phosphorus (mg/dL)	−0.041	0.684
Intact parathyroid hormone (pg/mL)	−0.098	0.333
Log-ANGPTL3 (ng/mL)	0.357	<0.001*

Notes: Data of the TG, glucose, BUN, Cre, and ANGPL3 levels showed skewed distribution and therefore were log-transformed before the analysis.

* P<0.05 is considered statistically significant in the univariate linear analyses.

Abbreviations: HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; eGFR, estimated glomerular filtration rate; ANGPTL3, angiopoietin-like protein 3; TG, triglycerides; BUN, blood urea nitrogen; Cre, creatinine.

Table 4 The multivariate stepwise linear regression analysis of the age, gender, height, body weight, and ANGPTL3: correlation to AIx levels among 100 patients with coronary artery disease

Items	β	Adjusted R^2	Adjusted R^2 change	P-value
Height (cm)	−0.269	0.123	0.123	0.007*
Log-ANGPTL3 (ng/mL)	0.259	0.174	0.051	0.010*

Note:

* P<0.05 is considered statistically significant in the multivariate stepwise linear regression analysis.

Abbreviations: ANGPTL3, angiopoietin-like protein 3; AIx, augmentation index.