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Case Series

Efficacy of denosumab in two cases with multiple-system atrophy and osteoporosis

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Pages 817-822 | Published online: 03 May 2018

Figures & data

Figure 1 Percentage changes in lumbar BMD (A) and total hip BMD (B) before, and at 6–8, 12, 18, and 24 months after denosumab therapy.

Note: Patient 2 was followed up for 18 months, not 24 months.
Abbreviations: BMD, bone mineral density; M, months.
Figure 1 Percentage changes in lumbar BMD (A) and total hip BMD (B) before, and at 6–8, 12, 18, and 24 months after denosumab therapy.

Figure 2 Percentage changes in BAP (A), urinary NTX (B), serum TRACP-5b (C), and active form of vitamin D or 1,25(OH)2D3 (D) before, and at 1, 4, 8, 12, 18, and 24 months after denosumab therapy.

Note: Patient 2 was followed up for 18 months, not 24 months.
Abbreviations: BAP, bone alkaline phosphatase; NTX, cross-linked N-terminal telopeptides of type I collagen; TRACP-5, tartrate-resistant acid phosphatase 5b; M, months.
Figure 2 Percentage changes in BAP (A), urinary NTX (B), serum TRACP-5b (C), and active form of vitamin D or 1,25(OH)2D3 (D) before, and at 1, 4, 8, 12, 18, and 24 months after denosumab therapy.

Table 1 Patient laboratory data

Table 2 Patient bone mineral density

Table 3 Patient laboratory data (bone metabolism markers)