The effect of hyoscine butylbromide in shortening the first stage of labor: A double blind, randomized, controlled, clinical trial

Figures & data

Table 1 Patient characteristics and incidence of labor

Characteristic	Control group (n = 45)	Hyoscine butylbromide group (n = 52)	P
Age (years)	24.4 (5.36)	23.9 (4.04)	0.638
Height (cm)	154.2 (10.38)	155.5 (5.61)	0.762
Weight (kg)	66.1 (12.93)	68.1 (11.95)	0.458
Gestational age (weeks)	39.4 (1.11)	39.4 (0.98)	0.683
Cervical dilatation (cm)	3 (3–4)	3 (3–4)	0.596
Spontaneous rupture of the membrane (yes/no)	10/35	23/29	0.039*

Notes: For patient characteristics, data are expressed as means (SD – standard deviation); for cervical dilation, data are median and interquartile range; for spontaneous rupture of the membrane, data are numbers.

* Significant difference between the two groups.

Figure 1 Mean durations of the first, second, and third stages of labor in the control group (group 2) and the hyoscine butylbromide group (group 1).

Notes: Vertical bars denote 0.95% confidence intervals. *P < 0.001 indicates a significant difference between the hyoscine butylbromide and control groups.

Table 2 Mean duration of first and second stage of labor

Stage of labor	Control group (n = 45)	Hyoscine butylbromide group (n = 52)	P
First stage (minutes)	214 (79)	165 (67)	<0.001
Second stage (minutes)	40 (34)	28 (20)	0.063
First + second stage (minutes)	251 (92)	190 (75)	<0.001

Note: Data are expressed as means (SD – standard deviation).

Table 3 Outcome of delivery

Outcome	Control group (n = 45)	Hyoscine butylbromide group (n = 52)	P
Instrumental delivery (yes/no)	6/39	6/46	0.967
Cesarean section (yes/no)	3/42	5/47	0.721
Postpartum hemorrhage (yes/no)	0/45	0/52	0.000
Tear (yes/no)	0/45	2/50	0.497
Apgar score (9–10 vs <9)	37/8	47/5	0.380

Table 4 Need for analgesia

Analgesia	Control group (n = 45)	Hyoscine butylbromide group (n = 52)	P
Meperidine	45	22	<0.001
No meperidine	0	30	–