Association between leptin gene rs7799039 polymorphism and lipid profile changes induced by isotretinoin treatment in acne patients

Figures & data

Table 1 Characteristics of acne patients of the current study (n = 200)

Variable	Patients, n%
Age (years; mean ± SD)	23.36 ± 6.449
Body mass index (kg/m^2; mean ± SD)	24.07 ± 3.802
Sex (male: female)	20.5: 79.5
Marital status, n (%)
Single	158 (79.0)
Married	42 (21.0)
Smoking
No	179 (89.5)
Yes	21 (10.5)
Most reported side effects, n (%)
Arthralgia/myalgia	155 (77.5)
Nosebleed	159 (79.5)
Headache	149 (74.5)

Table 2 Modulation of lipid profile and liver enzymes by isotretinoin therapy (n = 200)

Parameter	Measure	Before isotretinoin therapy	After isotretinoin therapy
Lipid profile (mmol/L)	HDL	1.41 ± 0.24	1.32 ± 0.32*
	LDL	2.33 ± 0.71	2.78 ± 0.76*
	TC	4.141 ± 0.88	4.61 ± 0.97*
	TG	0.99 ± 0.57	1.32 ± 0.77*
Liver function enzymes (U/L)	AST	18.61 ± 4.97	21.71 ± 9.84*
	ALT	15.71 ± 9.01	17.73 ± 12.30*

Notes: Data expressed as mean ± standard deviation.

* Significant difference (P < 0.01).

Abbreviations: AST, aspartate aminotransferase; ALT, alanine aminotransferase; HDL, high-density lipoprotein; LDL, low-density lipoprotein; TC, total cholesterol; TG, triglyceride.

Table 3 The impact of rs7799039 genotypes on biochemical parameters that are modulated by isotretinoin (n = 200)

Parameter	Genotypes (mean ± SD)
	CC	AC	AA
HDL (mmol/L)
Baseline	1.30 ± 0.29*	1.4 ± 0.27	1.37 ± 0.31
After treatment	1.26 ± 0.31*	1.36 ± 0.28	1.33 ± 0.29
% change	−9.54 ± 1.58*	−3.03 ± 1.77$	−9.54 ± 1.20
LDL (mmol/L)
Baseline	2.37 ± 0.61	2.30 ± 0.82	2.30 ± 0.62
After treatment	2.81 ± 0.70	2.80 ± 0.88	2.69 ± 0.55
% change	1.95 ± 2.08#	2.73 ± 2.11	2.02 ± 1.96
TC (mmol/L)
Baseline	4.02 ± 0.85	4.24 ± 0.98	4.10 ± 0.70
After treatment	4.55 ± 0.97	4.67 ± 1.09	4.59 ± 0.63
% change	1.03 ± 1.29$	1.44 ± 1.42	9.92 ± 1.25
TG (mmol/L)
Baseline	0.97 ± 0.55	1.04 ± 0.65	0.91 ± 0.40
After treatment	1.22 ± 0.71	1.45 ± 0.89	1.21 ± 0.50
% change	45.5 ± 116.9	40.6 ± 56.7	29.4 ± 44.4
AST (U/L)
Baseline	18.40 ± 4.12	19.46 ± 6.04£	17.00 ± 2.73
After treatment	20.61 ± 6.05	23.40 ± 10.0£	19.72 ± 4.75
% change	1.956 ± 3.70	1.88 ± 2.52	1.28 ± 3.72
ALT (U/L)
Baseline	15.56 ± 10.34	17.12 ± 9.35£	12.68 ± 3.26
After treatment	16.9 ± 9.15	19.44 ± 9.85£	15.14 ± 5.55
% change	17.41 ± 43.67	23.81 ± 50.69	14.07 ± 69.84

Notes:

* CC genotype is significantly different from AC genotype.

$ A significant difference of CC genotype with AC genotype.

# A significant difference of CC with other genotypes.

£ A significant difference of AC genotype with other genotypes.

Abbreviations: AST, aspartate aminotransferase; ALT, alanine aminotransferase; HDL, high-density lipoprotein; LDL, low-density lipoprotein; TC, total cholesterol; TG, triglyceride.