Anorexia nervosa versus hyperinsulinism: therapeutic effects of neuropharmacological manipulation

Figures & data

Table 1 Systolic, diastolic blood pressure, heart rate, noradrenaline, adrenaline, dopamine, platelet serotonin, and free blood serotonin blood values, at 0 minutes (resting), one minute (orthostasis), and five minutes (postexercise) in 22 patients with anorexia nervosa during a symptomatic period and during an asymptomatic period three months after treatment with amantadine 100 mg/day

	0 min	1 min	5 min	Pvalues
				0 vs 1 min	0 vs 5 min	1 vs 5 min
SBP ANs	152 ± 5	15 ± 3	17 ± 6	<0.05*	<0.02*	<0.02*
ANa	120 ± 3	12 ± 4	13 ± 6	ns	ns	ns
DBP ANs	60 ± 3	60 ± 2	61 ± 3	ns	ns	ns
ANa	74 ± 4	70 ± 4	76 ± 6	ns	ns	ns
HR ANs	71 ± 3	79 ± 4	83 ± 6	<0.02**	<0.01**	<0.01**
ANa	66 ± 6	64 ± 4	74 ± 6	ns	ns	ns
NA ANs	166 ± 4	169 ± 5	175 ± 5	ns	ns	ns
ANa	186 ± 6	214 ± 8	235 ± 7	<0.05*	<0.01**	<0.01**
Ad ANs	52 ± 2	67 ± 3	84 ± 4	<0.05*	<0.001***	<0.001***
ANa	27 ± 5	30 ± 4	35 ± 3	ns	ns	ns
DA ANs	18 ± 1	21 ± 2	23 ± 2	ns	ns	<0.05*
ANa	15 ± 4	20 ± 4	22 ± 5	ns	ns	ns
p5-HT ANs	228 ± 19	249 ± 22	225 ± 25	ns	ns	ns
ANa	258 ± 31	316 ± 27	308 ± 32	ns	ns	ns
f5-HT ANs	3.2 ± 1	13.7 ± 1	24.5 ± 2	<0.001***	<0.001***	<0.001***
ANa	2.1 ± 1	2.3 ± 1	3.1 ± 1	ns	ns	ns

Notes: Values are mean ± standard error of the mean.

* P < 0.05;

** P < 0.02;

*** P < 0.001.

Abbreviations: ANa, asymptomatic of anorexia nervosa; ANs, symptomatic of anorexia nervosa; DBP, diastolic blood pressure (mmHg); SBP, systolic blood pressure (mmHg); HR, heart rate (beats/min); NA, noradrenaline (pg/mL); Ad, adrenaline (pg/mL); DA, dopamine (pg/mL); p5-HT, platelet serotonin (ng/mL); f5-HT, free serotonin (ng/mL); ns, not significant.

Table 2 Significant correlations for physiological and plasma neurotransmitter parameters at 0 minutes (resting), one minute (orthostasis), and five minutes (postexercise) in 22 patients with anorexia nervosa during a symptomatic pretreatment period and during an asymptomatic period three months after treatment with amantadine 100 mg/day

	SBP	DBP	HR	NA	Ad	DA	p5-HT	f5-HT
ANs 0 min
HR	0.61*
Ad	0.66*		0.70*
DA					0.64*
f5-HT			0.70*		0.70*
ANa 0 min
HR	0.63*
ANs 1 min
HR	0.60*
Ad	0.60*		0.69**
DA					0.63**
f5-HT			0.60*		0.69*
ANa 1 min
Ad			0.63*
ANs 5 min
HR	0.70**
Ad	0.75**		0.80***
f5-HT			0.66*		0.68*

Notes:

* P< 0.05;

** P < 0.02;

*** P < 0.001.

Abbreviations: ANa, asymptomatic of anorexia nervosa; ANs, symptomatic of anorexia nervosa; DBP, diastolic blood pressure (mmHg); SBP, systolic blood pressure (mmHg); HR, heart rate (beats/min); NA, noradrenaline (pg/mL); Ad, adrenaline (pg/mL); DA, dopamine (pg/mL); p5-HT, platelet serotonin (ng/mL); f5-HT, free serotonin (ng/mL).