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Original Research

Clinical observation of immune checkpoint inhibitors in the treatment of advanced pancreatic cancer: a real-world study in Chinese cohort

, , , , , , , , , & show all
Pages 1691-1700 | Published online: 11 Sep 2018

Figures & data

Table 1 Characteristics of patients with advanced pancreatic cancer received

Figure 1 PD-1/PD-L1 inhibitor combined with double chemotherapy drugs.

Figure 1 PD-1/PD-L1 inhibitor combined with double chemotherapy drugs.

Table 2 The efficacy of patients with advanced pancreatic cancer received PD-1/PD-L1 inhibitor

Figure 2 Tumor response.

Notes: (A) Best change from baseline in terms of the sum of the largest target lesion diameter per patient. (B) Duration of exposure and best response per patient.
Abbreviation: RECIST, Response Evaluation Criteria in Solid Tumors.
Figure 2 Tumor response.

Figure 3 Kaplan–Meier estimates of progression-free survival and overall survival times.

Notes: (A) Kaplan–Meier plots of progression-free survival (PFS) in the full analytical set of patients with advanced pancreatic cancer who received PD-1/PD-L1 inhibitor treatment. (B) Kaplan–Meier plots of overall survival (OS) times in the full analytical set of patients with advanced pancreatic cancer who received PD-1/PD-L1 inhibitor treatment.
Figure 3 Kaplan–Meier estimates of progression-free survival and overall survival times.

Table 3 The survival of patients with advanced pancreatic cancer received PD-1/PD-L1 inhibitor

Figure 4 Kaplan–Meier plots of progression-free survival and overall survival times in the full analytical set of patients with advanced pancreatic cancer who received the PD-1/PD-L1 inhibitor in different lines of treatment.

Figure 4 Kaplan–Meier plots of progression-free survival and overall survival times in the full analytical set of patients with advanced pancreatic cancer who received the PD-1/PD-L1 inhibitor in different lines of treatment.

Table 4 Comparison of the survival of patients with advanced pancreatic cancer received PD-1/PD-L1 inhibitor in different lines of treatment

Figure 5 Kaplan–Meier estimates of progression-free survival and overall survival times.

Notes: (A) Kaplan–Meier plots of progression-free survival in the full analytical set of patients with advanced pancreatic cancer who received the PD-1/PD-L1 inhibitor in monotherapy and combined therapy. (B) Kaplan–Meier plots of overall survival times in the full analytical set of patients with advanced pancreatic cancer who received the PD-1/PD-L1 inhibitor in monotherapy and combined therapy.
Figure 5 Kaplan–Meier estimates of progression-free survival and overall survival times.

Table 5 Comparison of the efficacy and survival of patients with advanced pancreatic cancer received PD-1/PD-L1 inhibitor between monotherapy and combined therapy

Figure 6 Kaplan–Meier plots of progression-free survival in the full analytical set of patients with advanced pancreatic cancer who continued to receive the PD-1/PD-L1 inhibitor after the failure of PD-1/PD-L1 treatment.

Figure 6 Kaplan–Meier plots of progression-free survival in the full analytical set of patients with advanced pancreatic cancer who continued to receive the PD-1/PD-L1 inhibitor after the failure of PD-1/PD-L1 treatment.

Figure 7 The association between the response status and the percentage change in CA19-9 level.

Figure 7 The association between the response status and the percentage change in CA19-9 level.

Table 6 The efficacy of patients with different CA19-9 level changes

Figure 8 The efficacy of treatment in patients with different levels of PD-L1 expression.

Abbreviations: PD, progression of the disease; PR, partial remission; SD, stable disease.
Figure 8 The efficacy of treatment in patients with different levels of PD-L1 expression.

Table 7 The efficacy and survival of patients with genetic mutations

Table 8 Adverse events (AEs) in patients with advanced pancreatic cancer received immune checkpoint inhibitors