Duloxetine in the management of chronic musculoskeletal pain

Figures & data

Figure 1 Algorithm for topical/oral pharmacologic approach to the treatment of painful osteoarthritis.

Abbreviations: APAP, acetaminophen; dx, doxorubicin; NSAID, nonsteroidal antiinflammatory drug; PPI, proton pump inhibitor.

Table 1 Duloxetine adverse events for treatment of musculoskeletal pain

Chronic low back pain	Duloxetine 20/60/120 mg/day (N = 600)	Placebo (N = 441)
Nausea	16.2%	2.9%
Dry mouth	8.5%	2.0%
Insomnia	8.0%	3.6%
Somnolence	7.7%	1.4%
Constipation	7.3%	2.0%
Dizziness	6.3%	1.8%
Fatigue	6.3%	0.9%
Osteoarthritis	Duloxetine 60/120 mg/day (N = 239)	Placebo (N = 248)
Nausea	8.4%	2.0%
Fatigue	6.7%	0.8%
Constipation	5.9%	0.8%

Notes: Most common adverse events reported at a rate of ≥5% with duloxetine and at least twice the rate of placebo.Cymbalta^®.⁸³

Cymbalta^® full prescribing information; data on file with Lily Research Laboratories2011

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