Uncontrolled hyperlipidemia in Chinese patients who experienced acute coronary syndrome: an observational study

Figures & data

Figure 1 Flow diagram of patient enrolment.

Abbreviations: ACS, acute coronary syndrome; HDL-C, high-density lipoprotein-cholesterol; LDL-C, low-density lipoprotein-cholesterol; TC, total cholesterol; TG, triglycerides.

Table 1 Demographic and clinical characteristics of the index ACS event (eligible patients)

		Intensive statin therapy (N=1,493)	Maximum tolerated dose statin therapy (N=499)	Non-statin therapy (N=2)	Total (N=1,994)
Age, years	Mean (SD)	58.6 (8.88)	67.9 (9.36)	56.5 (7.78)	61.0 (9.84)
Gender
Female	N (%)	325 (21.8)	164 (32.9)	0	489 (24.5)
Male	N (%)	1,168 (78.2)	335 (67.1)	2 (100)	1,505 (75.5)
BMI, kg/m^2	Mean (SD)	24.90 (3.143)	23.90 (3.146)	31.20 (3.536)	24.65 (3.178)
Medical history
Hypertension	N (%)	824 (55.2)	308 (61.7)	1 (50.0)	1,133 (56.8)
Diabetes	N (%)	386 (25.9)	128 (25.7)	1 (50.0)	515 (25.8)
Smoking, n (%)
Never		552 (37.0)	240 (48.1)	1 (50.0)	793 (39.8)
Prior smoker		469 (31.4)	141 (28.3)	1 (50.0)	611 (30.6)
Current smoker		470 (31.5)	118 (23.6)	0	588 (29.5)
Physical inactivity	N (%)	131 (8.8)	41 (8.2)	0	172 (8.6)
Index ACS
ACS classification	N (%)
STEMI		820 (54.9)	248 (49.7)	0	1,068 (53.6)
NSTEMI		346 (23.2)	108 (21.6)	0	454 (22.8)
High-risk UA		320 (21.4)	139 (27.9)	2 (100)	461 (23.1)
In-hospital reperfusion
Cardiac catheterization	N (%)	247 (16.5)	93 (18.6)	1 (50.0)	341 (17.1)
PCI	N (%)	1,331 (89.1)	419 (84.0)	2 (100)	1,752 (87.9)
CABG	N (%)	4 (0.3)	3 (0.6)	0	7 (0.4)
Thrombolytic therapy	N (%)	10 (0.7)	4 (0.8)	0	14 (0.7)
Conservative therapy	N (%)	216 (14.5)	90 (18.0)	0	306 (15.3)

Abbreviations: ACS, acute coronary syndrome; BMI, body mass index; CABG, coronary artery bypass surgery; NSTEMI, non-ST segment elevation myocardial infarction; PCI, percutaneous intervention; STEMI, ST segment elevation myocardial infarction; UA, unstable angina.

Figure 2 Sequential graph representing the lipid profiles of study population on different lipid-lowering therapies.

Note: (A) Lipid profile at the onset of index ACS and (B) at enrollment (1 mmol/L =38.61 g/dL).
Abbreviations: ACS, acute coronary syndrome; HDL-C, high-density lipoprotein-cholesterol; LDL-C, low-density lipoprotein-cholesterol; TC, total cholesterol; TG, triglycerides.

Figure 3 Sequential graph representing the lipid profiles of patients not achieving target lipid levels on different statin therapies.

Note: (A) Lipid profile at the onset of index ACS and (B) at enrollment (1 mmol/L =38.61 g/dL).
Abbreviations: ACS, acute coronary syndrome; HDL-C, high-density lipoprotein-cholesterol; LDL-C, low-density lipoprotein-cholesterol; TC, total cholesterol; TG, triglycerides.

Table 2 Demographic and clinical characteristics of the index ACS event in patients not achieving lipid goal

		Intensive statin therapy (N=910)	Maximum tolerated dose statin therapy (N=362)	Non-statin therapy (N=1)	Total (N=1,273)
Age, years	Mean (SD)	58.5 (9.03)	67.9 (9.32)	51.0 (−)	61.2 (10.06)
Gender
Male	N (%)	698 (76.7)	236 (65.2)	1 (100)	935 (73.4)
Female	N (%)	212 (23.3)	126 (34.8)	0	338 (26.6)
BMI, kg/m^2	Mean (SD)	24.96 (3.207)	23.91 (3.072)	28.70 (−)	24.67 (3.204)
Medical history
Hypertension	N (%)	486 (53.4)	212 (58.6)	1 (100)	699 (54.9)
Diabetes	N (%)	233 (25.6)	89 (24.6)	0	322 (25.3)
Smoking	N (%)
Never		345 (37.9)	174 (48.1)	1 (100)	520 (40.8)
Prior smoker		264 (29.0)	93 (25.7)	0	357 (28.0)
Current smoker		300 (33.0)	95 (26.2)	0	395 (31.0)
Physical inactivity	N (%)	72 (7.9)	25 (6.9)	0	97 (7.6)
Index ACS
ACS classification	N (%)
STEMI		493 (54.2)	179 (49.4)	0	672 (52.8)
NSTEMI		219 (24.1)	77 (21.3)	0	296 (23.3)
High-risk UA		192 (21.1)	102 (28.2)	1 (100)	295 (23.2)

Abbreviations: ACS, acute coronary syndrome; BMI, body mass index; NSTEMI, non-ST segment elevation myocardial infarction; STEMI, ST segment elevation myocardial infarction; UA, unstable angina.

Table S1 Ethics committees which provided approval

Site number	Site name	Name of principle investigator
156001	Peking University First Hospital	Huo Yong/Li Jianping
156003	Beijing Tongren Hospital, Capital Medical University	Shi Xubo
156005	China-Japan Friendship Hospital	Ke Yuannan
156006	Beijing Anzhen Hospital, Capital Medical University	Zhou Yujie
156007	Fuwai Hospital CAMS&PUMC	Li Jianjun
156008	The Military General Hospital of Beijing PLA	Li Junxia
156009	The Central Hospital of China Aerospace Corporation	Wang Bin
156011	Daqing Oilfield General Hospital	Li Hui
156013	First Hospital of Jilin University	Zheng Yang
156014	Yanbian University Hospital	Li Xiang
156015	The People’s Hospital of Liaoning Province	Li Zhanquan
156020	Inner Mongolia People’s Hospital	Zhao Xingsheng
156021	Baotou Central Hospital	Zhao Ruiping
156022	The First Affiliated Hospital of Baotou Medical College	Lin Xuefeng
156023	People’s Liberation Army 254th Hospital	Guo Feng
156024	Second Hospital of Tianjin Medical University	Li Guangping
156025	TEDA International Cardiovascular Hospital	Lin Wenhua
156027	The First Hospital of Lanzhou University	Zhang Zheng
156028	Gansu Provincial Hospital	Xie Ping
156029	The First Affiliated Hospital of Xi’an JiaoTong University	Yuan Zuyi
156032	Jinan Central Hospital Affiliated to Shandong University	Su Guohai
156033	The Affiliated Hospital of Qingdao University	Cai Shanglang
156034	Nanjing Drum Tower Hospital	Xu Biao
156035	Zhongda Hospital, Southeast University	Ma Genshan
156036	The Second Affiliated Hospital of Soochow University	Xu Weiting
156038	Shanghai East Hospital	Liu Xuebo/Li Ying
156039	Ruijin Hospital Affiliated to Shanghai Jiaotong University	Zhang Ruiyan
156040	Shanghai Sixth People’s Hospital	Wei Meng
156042	Shanghai Tongji Hospital	Jiang Jinfa
156043	Shanghai First People’s Hospital	Liu Shaowen
156044	Zhongshan Hospital Fudan University	Ge Junbo
156050	Henan Provincial People’s Hospital	Gao Chuanyu
156051	Wuhan Asia Heart Hospital	Su Xi
156052	Hunan Provincial People’s Hospital	Guo Ying
156053	The Second Xiangya Hospital of Central South University	Peng Daoquan
156054	The First Affiliated Hospital of Nanchang University	Zheng Zeqi
156055	The Second Affiliated Hospital to Nanchang University	Cheng Xiaoshu
156056	West China Hospital, Sichuan University	Chen Mao
156057	Xinqiao Hospital of Third Military Medical University	Huang Lan
156058	First People’s Hospital of Yunnan Province	Zhang Hong
156059	The First Affiliated Hospital, Sun Yat-Sen University	Dong Yugang
156060	Guangdong General Hospital	Feng Yingqing
156061	Nanfang Hospital, Southern Medical University	Xu Dingli
156062	The Affiliated Hospital of Xuzhou Medical College	Zhu Hong
156063	Siping Central People’s Hospital	Wang Jianzhong
156064	Jilin Province People’s Hospital	Zhang Xuelian
156067	Tianjin People’s Hospital (Union Medicine Centre)	Yao Zhuhua
156071	Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University	Wang Jingfeng
156074	Lanzhou University Second Hospital	Bai Feng
156078	Zhejiang Provincial People’s Hospital	Qu Baiming
156082	Navy General Hospital	Li Tianchang
156083	No 4 Tianjing Central Hospital	Li Huanming
Sites initiated without subject
156041	Huashan Hospital Fudan University	Shi Haiming
156045	Shanghai Changzheng Hospital	Wu Zonggui