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Original Research

The possible effect of SCN1A and SCN2A genetic variants on carbamazepine response among Khyber Pakhtunkhwa epileptic patients, Pakistan

, &
Pages 2305-2313 | Published online: 21 Nov 2018

Figures & data

Figure 1 Schematic presentation of the study.

Abbreviation: CBZ, carbamazepine.
Figure 1 Schematic presentation of the study.

Figure 2 CONSORT diagram.

Abbreviation: CBZ, carbamazepine.
Figure 2 CONSORT diagram.

Table 1 Demographic features of the enrolled patients

Table 2 Dose and frequency of CBZ as monotherapy

Figure 3 Plasma level of CBZ vs different genotypes of SCN1A and SCN2A genes at the 3rd and 6th month of the therapy.

Notes: (A) Plasma level of CBZ vs SCN1A genotypes. (B) Plasma level of CBZ vs SCN2A genotypes. *Significant changes.
Abbreviation: CBZ, carbamazepine.
Figure 3 Plasma level of CBZ vs different genotypes of SCN1A and SCN2A genes at the 3rd and 6th month of the therapy.

Table 3 Mean plasma levels of CBZ in patients with SCN (1A and 2A) gene polymorphisms with its relative frequencies in poor seizure-controlled and seizure-controlled patients at 3rd month of CBZ therapy

Figure 4 Duration of seizures per week in nonresponder patients to CBZ on 3rd and 6th month of the therapy.

Abbreviation: CBZ, carbamazepine.
Figure 4 Duration of seizures per week in nonresponder patients to CBZ on 3rd and 6th month of the therapy.

Table 4 Mean plasma level of CBZ in patients with SCN (1A and 2A) gene polymorphisms with its relative frequencies in poor seizure-controlled and seizure-controlled patients at 6th month of CBZ therapy