Urinary orosomucoid: a new marker of cardiovascular risk in psoriatic patients?

Figures & data

Table 1 Clinical characteristics of the involved individuals

	Patients, n=114
Age, years	63±9.98
Male, n (%)	67 (59)
BMI, kg/m^2	29.78±7.81
DM type 1, n (%)	8 (0.07)
DM type 2, n (%)	21 (18)
Hypertension, n (%)	87 (76)
Smoking, n (%)	21 (18)
PASI	6.38±6.92
QRISK2017, %	19.1±10.69

Abbreviations: BMI, body mass index; DM, diabetes mellitus; PASI, Psoriasis Area Severity Index.

Table 2 Parameters of psoriatic patients based on the Psoriasis Area and Severity Index

Parameter	Mild PASI<7 N=78	Moderate PASI:7–12 N=20	Severe PASI>12 N=16	Mild vs Moderate p-value	Mild vs Severe p-value
hsCRP, mg/mL	2.6 (1.06–4.51)	2.8 (0.82–5.29)	5.9 (3.60–10.91)	n.s.	0.003
Uric acid	305.5 (259.5–365.5)	322.5 (276–369)	366 (283–440)	n.s.	n.s.
TAC	451.68 (372.12–514.71)	433.43 (368.63–502.35)	480.15 (371.63–543.52)	n.s.	n.s.
MDA	2.01 (1.47–2.28)	1.83 (1.46–2.28)	2.05 (1.31–2.49)	n.s.	n.s.
ADMA, μmol/L	0.66 (0.42–0.82)	0.70 (0.63–0.91)	0.65 (0.47–0.83)	n.s.	n.s.
L-arg, μmol/L	44.66 (33.61–61.89)	49.86 (21.64–90.66)	33.51 (27.47–86.66)	n.s.	n.s.
L-arg/ADMA ratio	225.92 (154.38–294.87)	179.55 (78.92–235.23)	162.15 (139.3–216.61)	n.s.	n.s.
s-ORM	0.76 (0.66–0.90)	0.74(0.59–0.92)	0.98 (0.81–1.12)	n.s.	0.005
u-ORM	0.598 (0.26–1.29)	1.87 (0.54–4.12)	0.99 (0.28–2.81)	0.003	n.s.
u-ORM/u-CREAT	0.06 (0.02–0.17)	0.17 (0.09–0.31)	0.10 (0.04–0.17)	0.005	n.s.
QRISK2017	18.9 (13.1–24.3)	17.36 (11.3–27.0)	17.1 (10.3–28.7)	n.s.	n.s.

Abbreviations: hsCRP, high sensitivity C-reactive protein; TAC, total antioxidant capacity; MDA, malondialdehyde; ADMA, asymmetric dimethylarginine; L-arg, L-arginine; se-ORM, serum orosomucoid; u-ORM, urinary orosomucoid; u-ORM/u-CREAT, urinary orosomucoid/urinary creatinine ratio.

Table 3 List of correlations

	QRISK	hsCRP	MDA	Uric acid	TAC	p-ORM	u-ORM	u-ORM/u-CREAT
QRISK	–	n.s.	n.s.	n.s.	n.s.	n.s.	0.245	0.309
hsCRP	n.s.	–	0.220	0.288	0.383	0.529	0.213	0.284
MDA	n.s.	0.220	–	n.s.	n.s.	n.s.	n.s.	n.s.
Uric acid	n.s.	0.288	n.s.	–	0.661	0.226	n.s.	n.s.
TAC	n.s.	0.383	n.s.	0.661	–	n.s.	n.s.	n.s.
s-ORM	n.s.	0.529	n.s.	0.226	n.s.	–	n.s.	n.s.
u-ORM	0.245	0.213	n.s.	n.s.	n.s.	n.s.	–	0.896
u-ORM/u-CREAT	0.309	0.284	n.s.	n.s.	n.s.	n.s.	0.896	–

Abbreviations: hsCRP, high sensitivity C-reactive protein; TAC. total antioxidant capacity; MDA, malondialdehyde; L-arg, L-arginine; se-ORM, serum orosomucoid; u-ORM, urinary orosomucoid; u-ORM/u-CREAT, urinary orosomucoid/urinary creatinine ratio.