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Therapeutics and Clinical Risk Management Volume 16, 2020 - Issue
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Original Research

Derivation and Validation of a Risk Prediction Model for Vancomycin-Associated Acute Kidney Injury in Chinese Population

Nana Xu1 Research Center of Clinical Pharmacy, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People’s Republic of China;2 Zhejiang Provincial Key Laboratory for Drug Evaluation and Clinical Research, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People’s Republic of ChinaView further author information
,
Qiao Zhang1 Research Center of Clinical Pharmacy, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People’s Republic of China;2 Zhejiang Provincial Key Laboratory for Drug Evaluation and Clinical Research, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People’s Republic of ChinaView further author information
,
Guolan Wu1 Research Center of Clinical Pharmacy, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People’s Republic of China;2 Zhejiang Provincial Key Laboratory for Drug Evaluation and Clinical Research, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People’s Republic of ChinaView further author information
,
Duo Lv1 Research Center of Clinical Pharmacy, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People’s Republic of China;2 Zhejiang Provincial Key Laboratory for Drug Evaluation and Clinical Research, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People’s Republic of ChinaView further author information
&
Yunliang Zheng1 Research Center of Clinical Pharmacy, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People’s Republic of China;2 Zhejiang Provincial Key Laboratory for Drug Evaluation and Clinical Research, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, People’s Republic of ChinaCorrespondence[email protected]
View further author information
Pages 539-550 | Published online: 22 Jun 2020

Figures & data

Figure 1 Flowing chart of population enrollment.

Figure 1 Flowing chart of population enrollment.

Table 1 Baseline Characteristics in the Derivation and Validation Cohorts

Table 2 Predictors Included in the Multivariable Logistic Regression Model

Figure 2 The AKI risk score nomogram for clinical application and AKI incidence by score decile.

Figure 2 The AKI risk score nomogram for clinical application and AKI incidence by score decile.

Figure 3 The ROC curve in the derivation (A) and external validation sets (B).

Figure 3 The ROC curve in the derivation (A) and external validation sets (B).

Figure 4 Calibration plot in the derivation and validation sets.

Figure 4 Calibration plot in the derivation and validation sets.

Figure 5 Incidence of AKI after treatment with vancomycin in both derivation and validation sets stratified by score quartiles: score <25 (very low risk), score 25–50 quartile (low risk), score 50–75 (moderate risk), and score ≥75 (high risk).

Figure 5 Incidence of AKI after treatment with vancomycin in both derivation and validation sets stratified by score quartiles: score <25 (very low risk), score 25–50 quartile (low risk), score 50–75 (moderate risk), and score ≥75 (high risk).

Table 3 Discriminative, Reclassification Ability and AIC of Our Established Risk Score in the Derivation and Validation Cohort in Comparison with Existing AKI Prediction Models in Patients Treated with Vancomycin

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