The Effect of 0.01% Atropine Eye Drops on the Ocular Surface in Children for the Control of Myopia—The Primary Results from a Six-Month Prospective Study

Figures & data

Table 1 Demographics and Ophthalmic Characteristics of the Participants

		Participants
No		72
Sex (n,%)	Male	40 (55.56%)
	Female	32 (44.44%)
Age		9.49 ± 1.61
AL (mm)		24.38 ± 0.84
K (D)		43.24 ± 1.37
ACD (mm)		3.77 ± 0.18
CCT (μm)		547.76 ± 30.79
IOP (mmHg)		15.28 ± 2.62
UCVA LOGMAR		0.40 ± 0.26
SE (DS)		−2.03 ± 1.21

Note: The continuous variables were expressed as means and standard deviations (SD).

Abbreviations: AL, axial Length; K, keratometry; ACD, anterior chamber depth; CCT, central cornea thickness; IOP, intraocular pressure; UCVA, uncorrected visual acuity; SE, spherical equivalent.

Table 2 Symptoms Prior to and After Using 0.01% Atropine

	Baseline	1 Month	3 Months	6 Months
No	72	72	71	65
Dry eye (n, %)	4 (5.56%)	2 (2.78%)	2 (2.82%)	1 (1.54%)
Itching (n, %)	1 (1.39%)	2 (2.78%)	2 (2.82%)	1 (1.54%)
Pink eye (n, %)	1(1.39%)	0	0	0
Discomfort* (n, %)	0	9 (12.5%)	0	0
Dazzled (n, %)	0	1 (1.39%)	0	0
Stye (n, %)	0	0	1 (1.41%)	0

Note: *Discomfort including soreness and mild tinglings.

Table 3 Comparisons of the Ocular Surface Parameters Between Baseline and Different Timepoints

	Baseline	1 Month	3 Months	6 Months	P
No	72	72	71	65
OSDI	0.08 ± 0.28	0.11 ± 0.32	0.06 ± 0.23	0.02 ± 0.12	0.089
TMH (mm)	0.23 ± 0.04	0.24 ± 0.04	0.23 ± 0.04	0.23 ± 0.04	0.294
TMA (mm^2)	0.0420 ± 0.0444	0.0385 ± 0.0174	0.0376 ± 0.0146	0.0381 ± 0.0145	0.459
NK-BUTfirst (s)	9.39 ± 5.25	9.66 ± 4.73	8.61 ± 4.16	10.22 ± 3.89	0.355
NK-BUTave (s)	10.49 ± 4.94	11.04 ± 4.36	10.10 ± 3.50	11.12 ± 3.20	0.336
BR	0.63 ± 0.37	0.53 ± 0.27	0.55 ± 0.34	0.49 ± 0.27	0.057
MS	0.89 ± 0.70	0.89 ± 0.70	0.88 ± 0.70	0.85 ± 0.62	1.000

Notes: The continuous variables were expressed as means and standard deviations (SD). Statistical comparisons between baseline and different time points were made with nonparametric Friedman test.

Abbreviations: OSDI, ocular surface disease index; TMH, tear meniscus height; TMA, tear meniscus area; NK-BUT_first, noninvasive first keratographic break-up time; NK-BUT_ave, noninvasive average keratographic break-up time; BR, bulbar redness; MS, meiboscore.